The reactions of organic azides and alkynes catalysed by copper species represent the
prototypical examples of click chemistry. The so-called CuAAC reaction (copper-catalysed …

The design of synthetic, monovalent host–guest molecular recognition pairs is still
challenging and of particular interest to inquire into the limits of the affinity that can be …

The Huisgen 1, 3-dipolar cycloaddition reaction of organic azides and alkynes1, 2 has
gained considerable attention in recent years due to the introduction in 2001 of Cu (1) …

Applications for advanced functional soft materials that possess precisely engineered
properties and functional groups have been expanding significantly with the development of …

Copper toxicity is a critical issue in the development of copper-based catalysts for copper (I)-
catalyzed azide–alkyne cycloaddition (CuAAC) reactions for applications in living systems …

The investigation of biological processes by chemical methods, commonly referred to as
chemical biology, often requires chemical access to biologically relevant macromolecules …

The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is one of the most broadly
applicable and easy-to-handle reactions in the arsenal of organic chemistry. However, the …

The concept of “click” chemistry, introduced by Sharpless and coworkers a couple of years
ago, promotes the use of efficient, selective and versatile chemical reactions in synthetic …

The development and applications of site-selective protein immobilization have undergone
significant advances in recent years. Notably the recent fusion of synthetic chemistry and …

Protein biochips are at the heart of many medical and bioanalytical applications. Increasing
interest has been focused on surface activation and subsequent functionalization strategies …