The complications of failure, neural injury and local anaesthetic toxicity are common to all
regional anaesthetic techniques, and individual techniques are associated with specific …

With the development of the newer long-acting amide local anesthetics, ropivacaine and
levobupivacaine, numerous animal studies of LA systemic toxicity have emerged. Because …

Purpose: Intra-articular use of 0.5% bupivacaine is common in arthroscopic surgery. This
study was conducted to test the hypotheses that (1) 0.5% bupivacaine is toxic to articular …

Intractable neuropathic pain often results from nerve injury. One immediate event in
damaged nerve is a sustained increase in spontaneous afferent activity, which has a well …

BACKGROUND: It is unclear whether improved metabolism or a “lipid sink” effect of lipid
infusion is responsible for the positive effects in local anesthetic-induced myocardial …

Ropivacaine (RVC) is an enantiomerically pure local anesthetic (LA) largely used in surgical
procedures, which presents physico-chemical and therapeutic properties similar to those of …

Despite significant advancements in total knee arthroplasty (TKA), managing postoperative
pain remains a substantial clinical challenge. With advances in surgical techniques and …

Introduction: The primary objective of this noncomparative study was to evaluate the
pharmacokinetics of ropivacaine during a 48–72‐h continuous epidural infusion of …

Methods Twenty adult burn patients (male and female) aged between 18 and 80 yr were
enrolled into the study. The patients had a total burn surface area (TBSA) of …

Although new drugs and techniques may improve outcomes when unintended high blood
levels of local anesthetics occur, the primary focus of daily practice should remain the …