The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …

Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many
organisms, ranging from simple invertebrates to mammals, including humans. Many seminal …

The seven-residue peptide N-acetyl-Lys-Leu-Val-Phe-Phe-Ala-Glu-NH2, called Aβ16-22
and representing residues 16− 22 of the full-length β-amyloid peptide associated with …

Accumulation of amyloid-β (Aβ) peptides in the brain has been suggested to be the primary
event in sequential progression of Alzheimer's disease (AD). Here, we use Drosophila to …

Background The definitive indicator of Alzheimer's disease (AD) pathology is the profuse
accumulation of amyloid-ß (Aß) within the brain. Various in vitro and cell-based models have …

A growing number of medical research teams have begun to explore the experimental
advantages of using a genetic animal model, the nematode worm Caenorhabditis elegans …

A systematic, rational search for chalcone derivatives with multifunctional behavior has been
carried out, with the support of a computer-assisted protocol (CADMA-Chem). A total of 568 …

Neurodegenerative diseases (NDD) are a group of illness with diverse clinical importance
and etiologies. NDD include motor neuron disease such as amyotrophic lateral sclerosis …

Alzheimer's disease is a progressive, neurodegenerative disorder characterized by senile
plaques and neurofibrillary components. Aβ (1–42) is a principal component of senile …

Oxidative stress is frequently caused by an excess of free radicals and has been associated
with a wide variety of health disorders. Therefore, finding strategies for scavenging free …