Copper is an essential nutrient whose redox properties make it both beneficial and toxic to
the cell. Recent progress in studying transition metal signalling has forged new links …

Recent studies found that unbalanced copper homeostasis affect tumor growth, causing
irreversible damage. Copper can induce multiple forms of cell death, including apoptosis …

Background Cuproptosis is a copper-dependent cell death mechanism that is associated
with tumor progression, prognosis, and immune response. However, the potential role of …

Uveal melanoma (UM) is the most prevalent primary intraocular malignant tumor with a high
lethal rate. Patients who undergo conventional enucleation treatments consistently suffer …

Breast cancer has become a serious threat to women's health. Cancer progression is mainly
derived from resistance to apoptosis induced by procedures or therapies. Therefore, new …

Highlights•Disulfiram, an anti-alcoholism drug, was found owing anti-tumor activity.•The
combination of Disulfiram and copper greatly enhances its anti-tumor efficacy.•Disulfiram in …

Breast cancer (BC) is now the most frequent and lethal cancer among women. Cuproptosis
is a newly identified programmed cell death process that has been connected to tumor …

Simple Summary To improve efficacy of solid cancer treatment, efforts have shifted towards
targeting both the cancer cells and the surrounding tumour tissue they grow in. The lysyl …

Copper is an essential transition metal frequently increased in cancer known to strongly
influence essential cellular processes. Targeted therapy protocols utilizing both novel and …

The significantly increased copper level in tumor tissues and serum indicates the close
association of copper ions with tumor development, making copper ions attractive targets in …