The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in
1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was …

MicroRNAs (miRNAs) are critical regulators of gene expression. As miRNAs are frequently
deregulated in many human diseases, including cancer and immunological disorders, it is …

MicroRNAs are important regulators of gene expression that control both physiological and
pathological processes such as development and cancer. Although their mode of action has …

Inherent difficulties with blocking many desirable targets using conventional approaches
have prompted many to consider using RNA interference (RNAi) as a therapeutic approach …

MicroRNAs are small non‐coding RNA guide molecules that regulate gene expression via
association with effector complexes and sequence‐specific recognition of target sites on …

Argonaute-bound microRNAs silence mRNA expression in a dynamic and regulated
manner to control organismal development, physiology, and disease. We employed …

Competition between mammalian RNAi-related gene silencing pathways is well
documented. It is therefore important to identify all classes of small RNAs to determine their …

MicroRNAs (miRNAs) control gene expression in animals, plants, and unicellular eukaryotes
by promoting degradation or repressing translation of target mRNAs. miRNA expression is …

MicroRNAs (miRNAs) provide new therapeutic targets for many diseases, while their myriad
roles in development and cellular processes make them fascinating to study. We still do not …

MicroRNA (miRNA) silencing fine-tunes protein output and regulates diverse biological
processes. Argonaute (Ago) proteins are the core effectors of the miRNA pathway. In lower …