Triggering receptor expressed on myeloid cells-1 (TREM-1) is expressed on the majority of
innate immune cells and to a lesser extent on parenchymal cells. Upon activation, TREM-1 …

Cardiovascular diseases are known to be the most fatal diseases worldwide.
Ischaemia/reperfusion (I/R) injury is at the centre of the pathology of the most common …

Environmental factors are the largest contributors to cardiovascular disease. Here we show
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …

Fibrosis is a common pathology in cardiovascular disease. In the heart, fibrosis causes
mechanical and electrical dysfunction, and in the kidney, it predicts the onset of renal failure …

Background: The adult mammalian heart has limited regenerative capacity, mostly
attributable to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous …

In a cell-free approach to regenerative therapeutics, transient application of paracrine factors
in vivo could be used to alter the behavior and fate of progenitor cells to achieve sustained …

Cardiac fibrosis, associated with a decreased extent of microvasculature and with disruption
of normal myocardial structures, results from excessive deposition of extracellular matrix …

The epicardium makes essential cellular and paracrine contributions to the growth of the
fetal myocardium and the formation of the coronary vasculature. However, whether the …

Rationale: Hypertrophied hearts switch from mainly using fatty acids (FAs) to an increased
reliance on glucose for energy production. It has been shown that preserving FA oxidation …

Transverse aortic constriction (TAC) in the mouse is a commonly used experimental model
for pressure overload-induced cardiac hypertrophy and heart failure. 1 TAC initially leads to …