[HTML][HTML] Glucagon-like peptide-1: A multi-faceted anti-inflammatory agent

SF Mehdi, S Pusapati, MS Anwar, D Lohana… - Frontiers in …, 2023 - frontiersin.org
Inflammation contributes to many chronic conditions. It is often associated with circulating
pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity …

Steatotic liver disease: pathophysiology and emerging pharmacotherapies

M Kokkorakis, E Muzurović, Š Volčanšek… - Pharmacological …, 2024 - Elsevier
Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype.
Consequently, the metabolic dysfunction-associated steatotic liver disease …

Glucagon‐like peptide agonists: a prospective review

Z Mariam, SK Niazi - Endocrinology, Diabetes & Metabolism, 2024 - Wiley Online Library
Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have emerged as
promising therapeutic options for addressing Type‐2 diabetes, obesity, and related …

Effects of once‐weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity

J Blundell, G Finlayson, M Axelsen… - Diabetes, Obesity …, 2017 - Wiley Online Library
Aim The aim of this trial was to investigate the mechanism of action for body weight loss with
semaglutide. Materials and methods This randomised, double‐blind, placebo‐controlled …

The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss

A Secher, J Jelsing, AF Baquero… - The Journal of clinical …, 2014 - jci.org
Liraglutide is a glucagon-like peptide-1 (GLP-1) analog marketed for the treatment of type 2
diabetes. Besides lowering blood glucose, liraglutide also reduces body weight. It is not fully …

Obesity and diabetes: an update

S Verma, ME Hussain - Diabetes & Metabolic Syndrome: Clinical Research …, 2017 - Elsevier
The twin epidemic of obesity and diabetes is a major crisis globally. Several epidemiologic
studies reveal the parallel escalation of obesity and diabetes. The term 'diabesity'expresses …

Weight loss variability with SGLT2 inhibitors and GLP‐1 receptor agonists in type 2 diabetes mellitus and obesity: mechanistic possibilities

E Brown, JPH Wilding, TM Barber, U Alam… - Obesity …, 2019 - Wiley Online Library
We are facing a global epidemic of obesity and type 2 diabetes. Weight loss, in the context of
obesity and type 2 diabetes, may improve glycaemic control and weight‐related …

Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease

DA Sandoval, DA D'Alessio - Physiological reviews, 2015 - journals.physiology.org
The preproglucagon gene (Gcg) is expressed by specific enteroendocrine cells (L-cells) of
the intestinal mucosa, pancreatic islet α-cells, and a discrete set of neurons within the …

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

H Ellingsgaard, I Hauselmann, B Schuler, AM Habib… - Nature medicine, 2011 - nature.com
Exercise, obesity and type 2 diabetes are associated with elevated plasma concentrations of
interleukin-6 (IL-6). Glucagon-like peptide-1 (GLP-1) is a hormone that induces insulin …

Glucagon-like peptide-1 receptor agonists and dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonists in the treatment of …

EM Muzurović, Š Volčanšek… - Journal of …, 2022 - journals.sagepub.com
The obesity pandemic is accompanied by increased risk of develo** metabolic syndrome
(MetS) and related conditions: non-alcoholic fatty liver disease (NAFLD)/non-alcoholic …