Regulation of signaling from the epidermal growth factor family

AW Burgess - The Journal of Physical Chemistry B, 2022 - ACS Publications
The epidermal growth factor (EGF) system has allowed chemists, biologists, and clinicians to
improve our understanding of cell production and cancer therapy. The discovery of EGF led …

Engineered synthetic nanobody-based biosensors for electrochemical detection of epidermal growth factor receptor

AF Cruz-Pacheco, Y Monsalve… - Chemical Engineering …, 2023 - Elsevier
Two engineered synthetic nanobody-based nanobiocomposite platforms were developed
for label-free electrochemical detection of the epithelial growth factor receptor (EGFR) …

Identification of meflin as a potential marker for mesenchymal stromal cells

K Maeda, A Enomoto, A Hara, N Asai, T Kobayashi… - Scientific reports, 2016 - nature.com
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) in culture are derived from BM
stromal cells or skeletal stem cells. Whereas MSCs have been exploited in clinical medicine …

LRIG proteins in glioma: functional roles, molecular mechanisms, and potential clinical implications

F Mao, B Wang, Q **ao, F Cheng, T Lei… - Journal of the Neurological …, 2017 - Elsevier
Gliomas are the most common intracranial tumors of the nervous system. These tumors are
characterized by unlimited cell proliferation and excessive invasiveness. Despite the …

LRIG1 is a conserved EGFR regulator involved in melanoma development, survival and treatment resistance

O Billing, Y Holmgren, D Nosek, H Hedman… - Oncogene, 2021 - nature.com
Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a pan-negative
regulator of receptor tyrosine kinase (RTK) signaling and a tumor suppressor in several …

Essential role of linx/Islr2 in the development of the forebrain anterior commissure

S Abudureyimu, N Asai, A Enomoto, L Weng… - Scientific reports, 2018 - nature.com
Linx is a member of the leucine-rich repeat and immunoglobulin family of membrane
proteins which has critical roles in the development of the peripheral nervous system and …

Harnessing LRIG1-mediated inhibition of receptor tyrosine kinases for cancer therapy

V Neirinckx, H Hedman, SP Niclou - … et Biophysica Acta (BBA)-Reviews on …, 2017 - Elsevier
Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an
endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently …

Hypothesis: Do LRIG proteins regulate stem cell quiescence by promoting BMP signaling?

C Herdenberg, H Hedman - Stem Cell Reviews and Reports, 2023 - Springer
Leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins are evolutionarily
conserved integral membrane proteins. Mammalian LRIG1 regulates stem cell quiescence …

LRIGs: A prognostically significant family with emerging therapeutic competence against cancers

U Malik, A Javed - Current Cancer Drug Targets, 2017 - ingentaconnect.com
The human leucine-rich repeats and immunoglobulin like domains (LRIG) are evolutionary
conserved family of single-pass transmembrane proteins. LRIG gene family includes three …

Analysis of toll‐like receptors in human milk: Detection of membrane‐bound and soluble forms

C Cattaneo, A Caramaschi, E Uga… - Journal of …, 2019 - Wiley Online Library
The bioactive and anti‐inflammatory role of human milk components has been recognized;
active milk components include soluble forms of Toll‐like receptors (TLRs). Preterm babies …