Visible-to-NIR-light activated release: from small molecules to nanomaterials

R Weinstain, T Slanina, D Kand, P Klan - Chemical reviews, 2020 - ACS Publications
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable)
protecting groups (PPGs), also known as caged or photocaged compounds, are used to …

Next-generation interfaces for studying neural function

JA Frank, MJ Antonini, P Anikeeva - Nature biotechnology, 2019 - nature.com
Monitoring and modulating the diversity of signals used by neurons and glia in a closed-loop
fashion is necessary to establish causative links between biochemical processes within the …

Structural Elucidation of a metagenomic urethanase and its engineering towards enhanced hydrolysis profiles

T Bayer, GJ Palm, L Berndt, H Meinert… - Angewandte Chemie …, 2024 - Wiley Online Library
While plastics like polyethylene terephthalate can already be degraded efficiently by the
activity of hydrolases, other synthetic polymers like polyurethanes (PUs) and polyamides …

Water-soluble BODIPY photocages with tunable cellular localization

D Kand, P Liu, MX Navarro, LJ Fischer… - Journal of the …, 2020 - ACS Publications
Photoactivation of bioactive molecules allows manipulation of cellular processes with high
spatiotemporal precision. The recent emergence of visible-light excitable photoprotecting …

Clip chemistry: diverse (bio)(macro) molecular and material function through breaking covalent bonds

P Shieh, MR Hill, W Zhang, SL Kristufek… - Chemical …, 2021 - ACS Publications
In the two decades since the introduction of the “click chemistry” concept, the toolbox of “click
reactions” has continually expanded, enabling chemists, materials scientists, and biologists …

Lysosome-targeted multifunctional lipid probes reveal the sterol transporter NPC1 as a sphingosine interactor

J Altuzar, J Notbohm, F Stein, P Haberkant… - Proceedings of the …, 2023 - pnas.org
Lysosomes are catabolic organelles involved in macromolecular digestion, and their
dysfunction is associated with pathologies ranging from lysosomal storage disorders to …

Fluorogenic chemical probes for wash-free imaging of cell membrane damage in ferroptosis, necrosis, and axon Injury

P Mauker, D Beckmann, A Kitowski… - Journal of the …, 2024 - ACS Publications
Selectively labeling cells with damaged membranes is needed not only for identifying dead
cells in culture, but also for imaging membrane barrier dysfunction in pathologies in vivo …

Light-triggered release of photocaged therapeutics-Where are we now?

JM Silva, E Silva, RL Reis - Journal of Controlled Release, 2019 - Elsevier
The current available therapeutics face several challenges such as the development of ideal
drug delivery systems towards the goal of personalized treatments for patients benefit. The …

Trifunctional lipid probes for comprehensive studies of single lipid species in living cells

D Höglinger, A Nadler, P Haberkant… - Proceedings of the …, 2017 - pnas.org
Lipid-mediated signaling events regulate many cellular processes. Investigations of the
complex underlying mechanisms are difficult because several different methods need to be …

Organelle‐targeted BODIPY photocages: visible‐light‐mediated subcellular photorelease

D Kand, L Pizarro, I Angel, A Avni… - Angewandte Chemie …, 2019 - Wiley Online Library
Photocaging facilitates non‐invasive and precise spatio‐temporal control over the release of
biologically relevant small‐and macro‐molecules using light. However, sub‐cellular …