Rho family GTPases are critical regulators of cellular functions that play important roles in
cancer progression. Aberrant activity of Rho small G-proteins, particularly Rac1 and their …

The Rho subfamily members of Rho GTPases, RhoA, RhoB, and RhoC, are key regulators
of signal transduction in a variety of cellular processes, including regulation of actomyosin …

Chemoresistance remains the uppermost disincentive for cancer treatment on account of
many genetic and epigenetic alterations. Long non-coding RNAs (lncRNAs) are emerging …

We have previously shown that miR-486-5p is one of the most downregulated micro RNAs
in lung cancer. The objective of the study was to investigate the role of miR-486-5p in the …

Cell adhesion to the extracellular matrix (ECM) is necessary for development of the
mammary gland, and to maintain the normal architecture and function of the gland. Cells …

RHO GTPases have been traditionally associated with protumorigenic functions. While this
paradigm is still valid in many cases, recent data have unexpectedly revealed that RHO …

The basal-like breast cancer (BLBC) subtype accounts for a disproportionately high
percentage of overall breast cancer mortality. The current therapeutic options for BLBC need …

Gastric cancer (GC) ranks among the top five malignant tumors worldwide by the incidence
and mortality rate. However, the mechanisms underlying its progression are poorly …

Rho GTPases are key regulators of actin and microtubule dynamics and organization.
Increasing evidence shows that many viruses have evolved diverse interactions with Rho …

Nasopharyngeal carcinoma (NPC) is a highly invasive and metastasis-prone epithelial
cancer. The paucity of effective treatment strategies for recurrent and metastatic NPC is the …