RNA therapeutics (RNATx) aim to treat diseases, including cancer, by targeting or
employing RNA molecules for therapeutic purposes. Amongst the most promising targets …

The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …

Epigenetics is a discipline that studies heritable changes in gene expression that do not
involve altering the DNA sequence. Over the past decade, researchers have shown that …

The epigenetic regulation of DNA-templated processes has been intensely studied over the
last 15 years. DNA methylation, histone modification, nucleosome remodeling, and RNA …

The central dogma of gene expression is that DNA is transcribed into messenger RNAs,
which in turn serve as the template for protein synthesis. The discovery of extensive …

Functional biomolecules, including small noncoding RNAs (ncRNAs), are released and
transmitted between mammalian cells via extracellular vesicles (EVs), including endosome …

Large intervening non-coding RNAs (lincRNAs) are pervasively transcribed in the genome,,
yet their potential involvement in human disease is not well understood,. Recent studies of …

Cancer is a disease of aberrant gene expression. While the genetic causes of cancer have
been intensively studied, it is becoming evident that a large proportion of cancer …

Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased
transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …