Microbiota–gut–brain axis mechanisms in the complex network of bipolar disorders: potential clinical implications and translational opportunities

MA Ortega, MA Álvarez-Mon, C García-Montero… - Molecular …, 2023 - nature.com
Bipolar disorders (BD) represent a severe leading disabling mental condition worldwide
characterized by episodic and often progressive mood fluctuations with manic and …

Microbiota–gut–brain axis and epilepsy: a review on mechanisms and potential therapeutics

M Ding, Y Lang, H Shu, J Shao, L Cui - Frontiers in Immunology, 2021 - frontiersin.org
The gut–brain axis refers to the bidirectional communication between the gut and brain, and
regulates intestinal homeostasis and the central nervous system via neural networks and …

Stress induced microglial activation contributes to depression

B Li, W Yang, T Ge, Y Wang, R Cui - Pharmacological research, 2022 - Elsevier
Major depressive disorder (MDD) is a debilitating neuropsychological disorder, which has
caused serious health and socio-economic burdens worldwide. A growing body of evidence …

Glioma-associated microglia/macrophages (GAMs) in glioblastoma: Immune function in the tumor microenvironment and implications for immunotherapy

C Lin, N Wang, C Xu - Frontiers in Immunology, 2023 - frontiersin.org
Glioma is a mixed solid tumor composed of neoplastic and non-neoplastic components.
Glioma-associated macrophages and microglia (GAMs) are crucial elements of the glioma …

Microglia and astrocytes in Alzheimer's disease: significance and summary of recent advances

Q Deng, C Wu, E Parker, TCY Liu, R Duan… - Aging and …, 2024 - pmc.ncbi.nlm.nih.gov
Alzheimer's disease, one of the most common forms of dementia, is characterized by a slow
progression of cognitive impairment and neuronal loss. Currently, approved treatments for …

Blood–brain barrier dysfunction in the pathogenesis of major depressive disorder

S Wu, Y Yin, L Du - Cellular and Molecular Neurobiology, 2022 - Springer
Major depression represents a complex and prevalent psychological disease that is
characterized by persistent depressed mood, impaired cognitive function and complicated …

[HTML][HTML] Targeting neuroinflammation by polyphenols: A promising therapeutic approach against inflammation-associated depression

MA Tayab, MN Islam, KAA Chowdhury… - Biomedicine & …, 2022 - Elsevier
Depression is the most prevalent and debilitating mental disorder that affects a substantial
number of people globally, hindering all aspects of their lives and leading to a high number …

Astrocytes as a target for therapeutic strategies in epilepsy: current insights

N Çarçak, F Onat, E Sitnikova - Frontiers in molecular neuroscience, 2023 - frontiersin.org
Astrocytes are specialized non-neuronal glial cells of the central nervous system,
contributing to neuronal excitability and synaptic transmission (gliotransmission). Astrocytes …

The crosstalk between neurons and glia in methamphetamine-induced neuroinflammation

S Shi, T Chen, M Zhao - Neurochemical Research, 2022 - Springer
Methamphetamine (METH), an illicit psycho-stimulant, is widely known as an addictive drug
that may cause neurotoxic effects. Previous researches on METH abuse have mainly …

[HTML][HTML] Astrocyte-derived exosomal lncRNA 4933431K23Rik modulates microglial phenotype and improves post-traumatic recovery via SMAD7 regulation

X He, Y Huang, Y Liu, X Zhang, Q Wang, Y Liu, X Ma… - Molecular Therapy, 2023 - cell.com
Astrocyte-microglial interaction plays a crucial role in brain injury-associated
neuroinflammation. Our previous data illustrated that astrocytes secrete microRNA, leading …