Survivin: A molecular biomarker in cancer

PK Jaiswal, A Goel, RD Mittal - Indian Journal of Medical …, 2015 - journals.lww.com
Survivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases
and blocks cell death, is highly expressed in most cancers and is associated with a poor …

The survivin molecule as a double‐edged sword in cellular physiologic and pathologic conditions and its role as a potential biomarker and therapeutic target in cancer

A Rafatmanesh, M Behjati, N Mobasseri… - Journal of Cellular …, 2020 - Wiley Online Library
Survivin is a member of the family of apoptosis inhibitory proteins with increased expression
level in most cancerous tissues. Evidence shows that survivin plays regulatory roles in …

Survivin signaling in clinical oncology: a multifaceted dragon

JR Kanwar, SK Kamalapuram… - Medicinal research …, 2013 - Wiley Online Library
Survivin is an inhibitor of apoptosis protein (IAP) family member preferentially expressed in a
myriad of clinical cancers. The complex functional mechanism and regulatory roles of …

BIRC5 Gene Polymorphisms Are Associated with a Higher Stage of Local and Regional Disease in Oral and Oropharyngeal Squamous Cell Carcinomas

I Mumlek, P Ozretić, M Sabol, M Leović… - International journal of …, 2023 - mdpi.com
Oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma
(OPSCC) are the most common types of cancers in the head and neck region (HNSCC) …

Role of survivin gene promoter polymorphism (− 31G> C) in susceptibility and survival of esophageal cancer in northern India

R Upadhyay, R Khurana, S Kumar, UC Ghoshal… - Annals of surgical …, 2011 - Springer
Abstract Background and Aim Survivin is an upregulated inhibitor of apoptosis protein in
esophageal cancer (EC), and a promoter region polymorphism (− 31G> C) in the survivin …

Two survivin polymorphisms are cooperatively associated with bladder cancer susceptibility

N Kawata, N Tsuchiya, Y Horikawa… - … journal of cancer, 2011 - Wiley Online Library
Abnormal survivin expression has been reported to be involved in many types of cancer. A
single‐nucleotide polymorphism (SNP), C‐31G, located in the promoter region of survivin …

Overview of role of survivin in cancer: expression, regulation, functions, and its potential as a therapeutic target

X Fang, X Cao, J **ao, Y Hu, M Chen… - Journal of Drug …, 2024 - Taylor & Francis
Survivin holds significant importance as a member of the inhibitor of apoptosis protein (IAP)
family due to its predominant expression in tumours rather than normal terminally …

Survivin gene polymorphism association with papillary thyroid carcinoma

N Yazdani, FA Sayahpour, V Haghpanah… - … -Research and Practice, 2012 - Elsevier
Survivin expression is correlated with suppression of apoptosis in human solid tumors. A
polymorphism at position− 31 (G/C)(rs 9904341) has been associated with cancer risk in …

[HTML][HTML] Polymorphisms in the survivin promoter are associated with age of onset of ovarian cancer

CH Han, Q Wei, KK Lu, Z Liu, GB Mills… - International journal of …, 2009 - ncbi.nlm.nih.gov
Survivin has been identified as an apoptosis inhibitor and a key regulator of mitosis. A
common polymorphism (-31G> C) at the survivin promoter has been extensively studied in …

Survivin SNP-carcinogen Interactions in Oral Cancer

CJ Weng, YH Hsieh, MK Chen… - Journal of dental …, 2012 - journals.sagepub.com
In Taiwan, oral cancer is causally associated with environmental carcinogens. Survivin is an
anti-apoptotic protein and is generally considered a marker of malignancy. The current study …