[HTML][HTML] Cationic Curcumin Nanocrystals Liposomes for Improved Oral Bioavailability: Formulation Development, Optimization, In Vitro and In Vivo Evaluation

X Cheng, X Han, J Si, C Dong, Z Ji, S Zhao, X Wu, H Li… - Pharmaceutics, 2024 - mdpi.com
Curcumin, a naturally occurring poorly water-soluble polyphenol with a broad spectrum, is a
typical BCS IV drug. The objective of this study was to develop curcumin nanocrystals …

Design and Bottom-up Production of an Aerosolizable Cannabidiol Nanosuspension

L Casula, M Schlich, MC Cardia, E Lai… - Molecular …, 2024 - ACS Publications
Cannabidiol (CBD), a small nonpsychoactive molecule derived from Cannabis sativa, exerts
a variety of therapeutic actions, such as anti-inflammatory, antioxidant, and antibacterial …

3D printed scaffolds as delivery devices for nanocrystals: A proof of concept loading Atorvastatin with enhanced properties for sublingual route of administration

BA Barrientos, DA Real, A Rossetti… - International Journal of …, 2024 - Elsevier
Increasing the solubility of drugs is a recurrent objective of pharmaceutical research, and
one of the most widespread strategies today is the formulation of nanocrystals (NCs) …

[HTML][HTML] Encapsulation of Nanocrystals in Mannitol-Based Inhalable Microparticles via Spray-Drying: A Promising Strategy for Lung Delivery of Curcumin

L Casula, EF Craparo, E Lai, C Scialabba, D Valenti… - Pharmaceuticals, 2024 - mdpi.com
Background/Objectives: Curcumin is well known for its great anti-inflammatory and
antioxidant efficacy, representing a potential strategy for the treatment of respiratory …

[HTML][HTML] 2-(Piperidin-3-yl) phthalimides reduce classical markers of cellular inflammation in LPS-challenged RAW 264.7 cells and also demonstrate potentially …

MT Scerba, D Tweedie, NH Greig - Bioorganic & Medicinal Chemistry …, 2024 - Elsevier
Herein, we report the synthesis of new 4-amino-2-(piperidin-3-yl) isoindoline-1, 3-diones
and their biological evaluation in a series of in vitro experiments. The synthetic production of …

Neuropathological role of alpha-synuclein: major contribution of inflammation in the evolution of both motor and non-motor symptoms of Parkinson's disease

MF Palmas - 2023 - tesidottorato.depositolegale.it
Neuroinflammation is nowadays considered a cardinal pathological feature of Parkinson's
disease (PD), in which glial cells lose their homeostatic function in favour of a pro …

NOVEL METHOD FOR DETERMINATION OF POMALIDOMIDE IN HUMAN PLASMA BY ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY MASS …

K Ponnusamya, K Natarasan, S Natesan… - Indian …, 2024 - search.ebscohost.com
The current investigation studied and verified an accurate Ultra performance liquid
chromatography mass spectroscopy/mass spectroscopy technique for the high-throughput …