MEK1/2 are critical components of the RAS–RAF–MEK–ERK or MAPK signalling pathway
that regulates a variety of cellular functions including proliferation, survival, and …

Tetrazole cycle is a promising pharmacophore fragment frequently used in the development
of novel drugs. This moiety is a stable, practically non-metabolized bioisosteric analog of …

Aim and Objective: In this review, we summarize the current state of varied multicomponent/
onepot protocols for synthesis of vital pyrazole derivatives under varied conditions, including …

An environmentally friendly catalyst-free synthesis protocol for functionalized 1, 4-
dihydropyridine derivatives involving four components under ultrasonic irradiation in …

A simple and versatile one-pot three-component synthetic protocol is devised for
heterocycles, viz. 2, 6-diamino-4-substituted-4H-pyran-3, 5-dicarbonitrile derivatives, in short …

A practical method is designated for the one-pot, multicomponent synthesis of 1, 4-
dihydropyridine derivatives by cyclo-condensation of aromatic aldehydes, 5, 5-dimethyl-1, 3 …

An operational approach for synthesis of eleven substituted 4H-chromene derivatives by
one-pot, three-component reaction of aromatic aldehyde, methyl cyanoacetate and cyclic …

Background: Globally, cancer is regarded as one of the biggest health concern in humans
and animals and is one of the most terrifying diseases. Therefore, there is a necessity for the …

A facile and an efficient procedure for the synthesis of poly‐substituted 1, 4‐dihydropyridine
derivatives under catalyst‐free conditions has been established by a one‐pot multi …

This work presents the preparation of a new series of N-(substituted phenyl)-2-(4-oxo-5-(4-
(thieno [2, 3-d]-pyrimidin-4-yloxy) benzylidene)-2-thioxothiazolidin-3-yl) acetamide …