Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

Neutrophils play a key role in defence against infection and in the activation and regulation
of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have …

Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T
cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a …

Map** single-cell sequencing profiles to comprehensive reference datasets provides a
powerful alternative to unsupervised analysis. However, most reference datasets are …

Myeloid cells are known to suppress antitumour immunity. However, the molecular drivers of
immunosuppressive myeloid cell states are not well defined. Here we used single-cell RNA …

Spatial omics data are advancing the study of tissue organization and cellular
communication at an unprecedented scale. Flexible tools are required to store, integrate and …

Immunotherapy is a mainstay of non-small cell lung cancer (NSCLC) management. While
tumor mutational burden (TMB) correlates with response to immunotherapy, little is known …

The full neutrophil heterogeneity and differentiation landscape remains incompletely
characterized. Here, we profiled> 25,000 differentiating and mature mouse neutrophils using …

Checkpoint blockade therapies have improved cancer treatment, but such immunotherapy
regimens fail in a large subset of patients. Conventional type 1 dendritic cells (DC1s) control …

Background Large-scale single-cell transcriptomic datasets generated using different
technologies contain batch-specific systematic variations that present a challenge to batch …