Heterogeneity describes the differences among cancer cells within and between tumors. It
refers to cancer cells describing variations in morphology, transcriptional profiles …

Rapid advances in high-throughput sequencing and a growing realization of the importance
of evolutionary theory to cancer genomics have led to a proliferation of phylogenetic studies …

Black box AI systems for automated decision making, often based on machine learning over
(big) data, map a user's features into a class or a score without exposing the reasons why …

Recurrent successions of genomic changes, both within and between patients, reflect
repeated evolutionary processes that are valuable for the anticipation of cancer progression …

Understanding how genotypes map onto phenotypes, fitness, and eventually organisms is
arguably the next major missing piece in a fully predictive theory of evolution. We refer to this …

Right-sided colon cancer (RCC) has worse prognosis compared to left-sided colon cancer
(LCC) and rectal cancer. The reason for this difference in outcomes is not well understood …

Grasslands are widespread elements of urban greenspace providing recreational,
psychological and aesthetic benefits to city residents. Two urban grassland types of …

Carcinogenesis results from the sequential acquisition of oncogenic mutations that convert
normal cells into invasive, metastasizing cancer cells. Colorectal cancer exemplifies this …

Cancer progression is an evolutionary process shaped by both deterministic and stochastic
forces. Multi-region and single-cell sequencing of tumors enable high-resolution …

Recurring sequences of genomic alterations occurring across patients can highlight
repeated evolutionary processes with significant implications for predicting cancer …