Enhancer sequences control gene expression and comprise binding sites (motifs) for
different transcription factors (TFs). Despite extensive genetic and computational studies, the …

Myosin storage myopathy (MSM) is a rare skeletal muscle disorder caused by mutations in
the slow muscle/β-cardiac myosin heavy chain (MHC) gene. MSM missense mutations …

Enhancers are crucial cis-regulatory elements that control gene expression in a cell-type-
specific manner. Despite extensive genetic and computational studies, accurately predicting …

Homeodomain transcription factors (TFs) bind to specific DNA sequences to regulate the
expression of target genes. Structural work has provided insight into molecular identities and …

Motivation Sequence-based deep learning approaches have been shown to predict a
multitude of functional genomic readouts, including regions of open chromatin and RNA …

The Drosophila PAX6 homolog twin of eyeless (toy) sits at the pinnacle of the genetic
pathway controlling eye development, the retinal determination network. Expression of toy in …

Enhancer sequences control gene expression and comprise binding sites (motifs) for
different transcription factors (TFs). Despite extensive genetic and computational studies, the …

A common way to investigate gene regulatory mechanisms is to identify differentially
expressed genes using transcriptomics, find their candidate enhancers using epigenomics …

Gene transcription refers to the process in which coding regions on the genome are copied
into mRNA molecules through complex cellular mechanisms. This process is regulated …