Inflammation-associated diseases encompass a range of infectious diseases and non-
infectious inflammatory diseases, which continuously pose one of the most serious threats to …

Infectious diseases pose serious threats to public health worldwide. Conventional diagnostic
methods for infectious diseases often exhibit low sensitivity, invasiveness, and long …

Liquid biopsies enable early detection and monitoring of diseases such as cancer, but their
sensitivity remains limited by the scarcity of analytes such as cell-free DNA (cfDNA) in blood …

CRISPR-Cas system has evolved as a highly preferred genetic engineering tool to perform
target gene manipulation via alteration of the guide RNA (gRNA) sequence. The ability to …

Mycobacterium tuberculosis (M. tb) effectively manipulates the host processes to establish
the deadly respiratory disease, Tuberculosis (TB). M. tb has developed key mechanisms to …

Tuberculosis (TB) remains a major underdiagnosed public health threat worldwide, being
responsible for more than 10 million cases and one million deaths annually. TB diagnosis …

How to realize fM-level detection of viral DNA without target amplification is a challenge.
Traditionally, preamplification of low-abundant DNA targets is a prerequisite, which not only …

Object Mycobacterium tuberculosis (MTB) is a bacterium that can cause zoonoses by
aerosol transmission. Tuberculosis (TB) caused by MTB heavily burdens world public health …

The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated (Cas) proteins are adaptive immune system found in bacteria and archaea. This …

Contaminants, such as nucleic acids or toxic small molecules, threaten both human health
and ecosystems when they infiltrate the environment. The precise and highly sensitive …