Organoids

Z Zhao, X Chen, AM Dowbaj, A Sljukic… - Nature Reviews …, 2022 - nature.com
Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

Artificial intelligence in cancer target identification and drug discovery

Y You, X Lai, Y Pan, H Zheng, J Vera, S Liu… - … and Targeted Therapy, 2022 - nature.com
Artificial intelligence is an advanced method to identify novel anticancer targets and discover
novel drugs from biology networks because the networks can effectively preserve and …

SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity

C Guo, Z You, H Shi, Y Sun, X Du, G Palacios, C Guy… - Nature, 2023 - nature.com
Cancer cells evade T cell-mediated killing through tumour–immune interactions whose
mechanisms are not well understood,. Dendritic cells (DCs), especially type-1 conventional …

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer's disease pathology

W Su, J Saravia, I Risch, S Rankin, C Guy… - Nature …, 2023 - nature.com
Neurodegenerative diseases, including Alzheimer's disease (AD), are characterized by
innate immune-mediated inflammation, but functional and mechanistic effects of the …

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

D Saul, RL Kosinsky, EJ Atkinson, ML Doolittle… - Nature …, 2022 - nature.com
Although cellular senescence drives multiple age-related co-morbidities through the
senescence-associated secretory phenotype, in vivo senescent cell identification remains …

Enrichr-KG: bridging enrichment analysis across multiple libraries

JE Evangelista, Z **e, GB Marino… - Nucleic acids …, 2023 - academic.oup.com
Gene and protein set enrichment analysis is a critical step in the analysis of data collected
from omics experiments. Enrichr is a popular gene set enrichment analysis web-server …

Convergent selection of a WD40 protein that enhances grain yield in maize and rice

W Chen, L Chen, X Zhang, N Yang, J Guo, M Wang… - Science, 2022 - science.org
A better understanding of the extent of convergent selection among crops could greatly
improve breeding programs. We found that the quantitative trait locus KRN2 in maize and its …

A clinically applicable integrative molecular classification of meningiomas

F Nassiri, J Liu, V Patil, Y Mamatjan, JZ Wang… - Nature, 2021 - nature.com
Meningiomas are the most common primary intracranial tumour in adults. Patients with
symptoms are generally treated with surgery as there are no effective medical therapies. The …

Neuromaps: structural and functional interpretation of brain maps

RD Markello, JY Hansen, ZQ Liu, V Bazinet, G Shafiei… - Nature …, 2022 - nature.com
Imaging technologies are increasingly used to generate high-resolution reference maps of
brain structure and function. Comparing experimentally generated maps to these reference …

Persistent serum protein signatures define an inflammatory subcategory of long COVID

A Talla, SV Vasaikar, GL Szeto, MP Lemos… - Nature …, 2023 - nature.com
Long COVID or post-acute sequelae of SARS-CoV-2 (PASC) is a clinical syndrome featuring
diverse symptoms that can persist for months following acute SARS-CoV-2 infection. The …