Axonal transport: cargo-specific mechanisms of motility and regulation
Axonal transport is essential for neuronal function, and many neurodevelopmental and
neurodegenerative diseases result from mutations in the axonal transport machinery …
neurodegenerative diseases result from mutations in the axonal transport machinery …
Microtubule assembly, organization and dynamics in axons and dendrites
During the past decade enormous advances have been made in our understanding of the
basic molecular machinery that is involved in the development of neuronal polarity. Far from …
basic molecular machinery that is involved in the development of neuronal polarity. Far from …
Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci
Analysis of de novo CNVs (dnCNVs) from the full Simons Simplex Collection (SSC)(N=
2,591 families) replicates prior findings of strong association with autism spectrum disorders …
2,591 families) replicates prior findings of strong association with autism spectrum disorders …
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
P Pasinelli, RH Brown - Nature Reviews Neuroscience, 2006 - nature.com
Amyotrophic lateral sclerosis (ALS) is a paralytic disorder caused by motor neuron
degeneration. Mutations in more than 50 human genes cause diverse types of motor neuron …
degeneration. Mutations in more than 50 human genes cause diverse types of motor neuron …
[HTML][HTML] Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases
F Martinon, J Tschopp - Cell, 2004 - cell.com
Caspases not only play an essential role during apoptotic cell death, but a subfamily of them—
the inflammatory caspases—are associated with immune responses to microbial pathogens …
the inflammatory caspases—are associated with immune responses to microbial pathogens …
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disorder resulting
from motor neuron death. Approximately 10% of cases are familial (FALS), typically with a …
from motor neuron death. Approximately 10% of cases are familial (FALS), typically with a …
AAA+ superfamily ATPases: common structure–diverse function
T Ogura, AJ Wilkinson - Genes to Cells, 2001 - Wiley Online Library
The AAA+ superfamily of ATPases, which contain a homologous ATPase module, are found
in all kingdoms of living organisms where they participate in diverse cellular processes …
in all kingdoms of living organisms where they participate in diverse cellular processes …
Mutations disrupting neuritogenesis genes confer risk for cerebral palsy
In addition to commonly associated environmental factors, genomic factors may cause
cerebral palsy. We performed whole-exome sequencing of 250 parent–offspring trios, and …
cerebral palsy. We performed whole-exome sequencing of 250 parent–offspring trios, and …
Lipid droplet contact sites in health and disease
After having been disregarded for a long time as inert fat drops, lipid droplets (LDs) are now
recognized as ubiquitous cellular organelles with key functions in lipid biology and beyond …
recognized as ubiquitous cellular organelles with key functions in lipid biology and beyond …
The tubulin code
Microtubules create diverse arrays with specific cellular functions such as the mitotic spindle,
cilia, and bundles inside neurons. How microtubules are regulated to enable specific …
cilia, and bundles inside neurons. How microtubules are regulated to enable specific …