Metabolic inflammation and insulin resistance in obesity
Obesity is becoming an epidemic in the United States and worldwide and increases risk for
many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular …
many diseases, particularly insulin resistance, type 2 diabetes mellitus, and cardiovascular …
The role of T cells in age-related diseases
Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting
in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue …
in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue …
Obesity-associated microbiomes instigate visceral adipose tissue inflammation by recruitment of distinct neutrophils
D Shantaram, R Hoyd, AM Blaszczak, L Antwi… - Nature …, 2024 - nature.com
Neutrophils are increasingly implicated in chronic inflammation and metabolic disorders.
Here, we show that visceral adipose tissue (VAT) from individuals with obesity contains …
Here, we show that visceral adipose tissue (VAT) from individuals with obesity contains …
The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals
Metabolic diseases are the most common and rapidly growing health issues worldwide. The
massive population-based human genetics is crucial for the precise prevention and …
massive population-based human genetics is crucial for the precise prevention and …
Aging, obesity, and inflammatory age-related diseases
The increase in the prevalence of obesity represents a worldwide phenomenon in all age
groups and is pathologically and genetically correlated with several metabolic and …
groups and is pathologically and genetically correlated with several metabolic and …
The macrophage switch in obesity development
Immune cell infiltration in (white) adipose tissue (AT) during obesity is associated with the
development of insulin resistance. In AT, the main population of leukocytes are …
development of insulin resistance. In AT, the main population of leukocytes are …
Adipose tissue inflammation in obesity: a metabolic or immune response?
Highlights•Immunometabolism of the adipose tissue affects insulin resistance and
obesity.•Type 2 immune response protects against diet-induced obesity.•Cytokines …
obesity.•Type 2 immune response protects against diet-induced obesity.•Cytokines …
Immune regulation of metabolic homeostasis in health and disease
Obesity is an increasingly prevalent disease worldwide. While genetic and environmental
factors are known to regulate the development of obesity and associated metabolic …
factors are known to regulate the development of obesity and associated metabolic …
The differential roles of T cells in non-alcoholic fatty liver disease and obesity
MA Van Herck, J Weyler, WJ Kwanten… - Frontiers in …, 2019 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) constitutes a spectrum of disease states
characterized by hepatic steatosis and is closely associated to obesity and the metabolic …
characterized by hepatic steatosis and is closely associated to obesity and the metabolic …
Interferon gamma mediates the reduction of adipose tissue regulatory T cells in human obesity
D Bradley, AJ Smith, A Blaszczak, D Shantaram… - Nature …, 2022 - nature.com
Decreased adipose tissue regulatory T cells contribute to insulin resistance in obese mice,
however, little is known about the mechanisms regulating adipose tissue regulatory T cells …
however, little is known about the mechanisms regulating adipose tissue regulatory T cells …