Fluid transport in the brain
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …
wakefulness, the brain is geared fully toward processing information and behaving, while …
The glymphatic system: Current understanding and modeling
We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …
Impaired glymphatic function and clearance of tau in an Alzheimer's disease model
The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with
interstitial fluid (ISF), may provide a clearance pathway for protein species such as amyloid …
interstitial fluid (ISF), may provide a clearance pathway for protein species such as amyloid …
The glymphatic system: implications for drugs for central nervous system diseases
In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …
known as the glymphatic system has grown. According to the glymphatic system concept …
Perivascular spaces in the brain: anatomy, physiology and pathology
Perivascular spaces include a variety of passageways around arterioles, capillaries and
venules in the brain, along which a range of substances can move. Although perivascular …
venules in the brain, along which a range of substances can move. Although perivascular …
Blood-brain barrier: from physiology to disease and back
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …
pathogens from entering the brain. At the same time, the BBB regulates transport of …
The glymphatic pathway in neurological disorders
Background The glymphatic (glial-lymphatic) pathway is a fluid-clearance pathway identified
in the rodent brain in 2012. This pathway subserves the flow of CSF into the brain along …
in the rodent brain in 2012. This pathway subserves the flow of CSF into the brain along …
Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
MD Sweeney, AP Sagare, BV Zlokovic - Nature Reviews Neurology, 2018 - nature.com
The blood–brain barrier (BBB) is a continuous endothelial membrane within brain
microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells …
microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells …
Sleep deprivation impairs molecular clearance from the human brain
It remains an enigma why human beings spend one-third of their life asleep. Experimental
data suggest that sleep is required for clearance of waste products from brain metabolism …
data suggest that sleep is required for clearance of waste products from brain metabolism …
Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport
Perivascular spaces are important highways for fluid and solute transport in the brain
enabling efficient waste clearance during sleep. However, the underlying mechanisms …
enabling efficient waste clearance during sleep. However, the underlying mechanisms …