In the 1970s, an unknown virus was suspected for documented cases of transfusion-
associated hepatitis, a phenomenon called non-A, non-B hepatitis. In 1989, the infectious …

Chronic liver injury leads to liver inflammation and fibrosis, through which activated
myofibroblasts in the liver secrete extracellular matrix proteins that generate the fibrous scar …

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease, with
approximately 71 million chronically infected individuals worldwide. Clinical care for patients …

Abstract Exhausted CD8 T cells (TEX) are a distinct state of T cell differentiation associated
with failure to clear chronic viruses and cancer. Immunotherapies such as PD-1 blockade …

HCV infection, risk-based screening failed to identify the majority of individuals with HCV
infection due to both clinician and patient barriers.(9-12) Analysis of the 2003-2010 National …

The ongoing worldwide pandemic due to COVID-19 has created awareness toward
ensuring best practices to avoid the spread of microorganisms. In this regard, the research …

Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs
categorized into 13 functional groups have been formally approved for the treatment of the …

Background: Rapid improvements in hepatitis C virus (HCV) therapy have led to the
approval of multiple oral direct-acting antiviral (DAA) regimens by the US Food and Drug …

Viperin is an interferon-induced cellular protein that is conserved in animals. It has
previously been shown to inhibit the replication of multiple viruses by producing the …