Hfq chaperone brings speed dating to bacterial sRNA

A Santiago‐Frangos… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Hfq is a ubiquitous, Sm‐like RNA binding protein found in most bacteria and some archaea.
Hfq binds small regulatory RNAs (sRNAs), facilitates base pairing between sRNAs and their …

Bacterial small RNA-based negative regulation: Hfq and its accomplices

N De Lay, DJ Schu, S Gottesman - Journal of Biological Chemistry, 2013 - ASBMB
A large group of bacterial small regulatory RNAs (sRNAs) use the Hfq chaperone to mediate
pairing with and regulation of mRNAs. Recent findings help to clarify how Hfq acts and …

Regulation of Hfq by the RNA CrcZ in Pseudomonas aeruginosa Carbon Catabolite Repression

E Sonnleitner, U Bläsi - PLoS Genetics, 2014 - journals.plos.org
Carbon Catabolite repression (CCR) allows a fast adaptation of Bacteria to changing
nutrient supplies. The Pseudomonas aeruginosa (PAO1) catabolite repression control …

Small RNA binding to the lateral surface of Hfq hexamers and structural rearrangements upon mRNA target recognition

E Sauer, S Schmidt… - Proceedings of the …, 2012 - National Acad Sciences
The bacterial Sm-like protein Hfq is a central player in the control of bacterial gene
expression. Hfq forms complexes with small regulatory RNAs (sRNAs) that use …

Small RNAs and their role in biofilm formation

JR Chambers, K Sauer - Trends in microbiology, 2013 - cell.com
The formation of biofilms is initiated by bacteria transitioning from the planktonic to the
surface-associated mode of growth. Several regulatory systems have been described to …

Proteins that chaperone RNA regulation

SA Woodson, S Panja… - Microbiology …, 2018 - Am Soc Microbiol
ABSTRACT RNA-binding proteins chaperone the biological functions of noncoding RNA by
reducing RNA misfolding, improving matchmaking between regulatory RNA and targets, and …

The bacterial protein Hfq: much more than a mere RNA-binding factor

P Sobrero, C Valverde - Critical reviews in microbiology, 2012 - Taylor & Francis
Most of the sequenced bacterial genomes contain a gene encoding a protein known as Hfq
that resembles the eukaryotic RNA-binding proteins of the LSm family. It was originally …

Recognition of the small regulatory RNA RydC by the bacterial Hfq protein

D Dimastrogiovanni, KS Fröhlich, KJ Bandyra… - Elife, 2014 - elifesciences.org
Bacterial small RNAs (sRNAs) are key elements of regulatory networks that modulate gene
expression. The sRNA RydC of Salmonella sp. and Escherichia coli is an example of this …

Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa

E Sonnleitner, A Wulf, S Campagne, XY Pei… - Nucleic acids …, 2018 - academic.oup.com
In Pseudomonas aeruginosa the RNA chaperone Hfq and the c atabolite r epression c ontrol
protein (Crc) act as post-transcriptional regulators during carbon catabolite repression …

Cycling of RNAs on hfq

EGH Wagner - RNA biology, 2013 - Taylor & Francis
The RNA chaperone Hfq is a key player in small RNA (sRNA)-mediated regulation of target
mRNAs in many bacteria. The absence of this protein causes pleiotropic phenotypes such …