Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials
in a non-disruptive and non-invasive manner. The obtained molecular properties at …

Internuclear distances represent one of the main structural constraints in molecular structure
determination using solid-state NMR spectroscopy, complementing chemical shifts and …

As a promising strategy, amorphous solid dispersion has been extensively employed in
improving the oral bioavailability of insoluble drugs. Despite the numerous advantages, the …

Oral administration of drugs is preferred over other routes for several reasons: it is non-
invasive, easy to administer, and easy to store. However, drug formulation for oral …

Molecules at a liquid/vapor interface have different organizations and mobilities from those
in the bulk. These differences potentially influence the rate of crystal nucleation, but the …

Common energy-intensive processes applied in oral solid dosage development, such as
milling, sieving, blending, compaction, etc. generate particles with surface and bulk crystal …

Through matrix crystallization, an amorphous solid may transform directly into its more stable
crystalline state, reducing the driving force for dissolution. Herein, the mechanism of matrix …

Pharmaceutical amorphous solid dispersions (ASDs) represent a widely used technology to
increase the bioavailability of active pharmaceutical ingredients (APIs). ASDs are based on …

In the pharmaceutical industry, poorly water-soluble drugs require enabling technologies to
increase apparent solubility in the biological environment. Amorphous solid dispersion …