Ruthenium complexes: an emerging ground to the development of metallopharmaceuticals for cancer therapy

M Abid, F Shamsi, A Azam - Mini Reviews in Medicinal …, 2016 - ingentaconnect.com
GLOBOCAN 2012 estimates 14.1 million new cancer cases and 8.2 million cancer-related
deaths worldwide. Cancer is rapidly becoming a major public health concern in India as …

Ruthenium complexes as potential cancer cell growth inhibitors for targeted chemotherapy

S Katheria - ChemistrySelect, 2022 - Wiley Online Library
The effective clinical use of the three generation platinum anticancer drugs, cisplatin,
carboplatin, and oxaliplatin, has sparked interest in metallodrugs; however, drug resistance …

Ru (II)/amino acid complexes inhibit the progression of breast cancer cells through multiple mechanism-induced apoptosis

F Mello-Andrade, APM Guedes, WC Pires… - Journal of Inorganic …, 2022 - Elsevier
For some cancer subtypes, such as triple-negative breast cancer, there are no specific
therapies, which leads to a poor prognosis associated with invasion and metastases …

A biphosphinic ruthenium complex with potent anti-bacterial and anti-cancer activity

JM da Silveira Carvalho, AH de Morais Batista… - New Journal of …, 2017 - pubs.rsc.org
Metal-based compounds have emerged as a novel strategy to improve our arsenal of
medicines. Among these compounds, carbon monoxide donor agents have been developed …

Anti-melanoma effect of ruthenium (II)-diphosphine complexes containing naphthoquinone ligand

F Rinaldi-Neto, AB Ribeiro, NH Ferreira… - Journal of Inorganic …, 2021 - Elsevier
The use of natural products as potential ligands has been explored as a strategy in the
development of metal-based chemotherapy. Since ruthenium complexes are promising …

Development of arene ruthenium antitumor complexes

W Su, Z Tang, P Li - Mini reviews in medicinal chemistry, 2016 - benthamdirect.com
The organometallic arene ruthenium complexes are rapidly advancing. In particular, the
organoruthenium complexes of the type [(η6-arene) Ru (X)(Y)(Z)] have attracted increasing …

Ruthenium (II) complexes as potential apoptosis inducers in chemotherapy

K Zheng, Q Wu, C Wang, W Tan… - Anti-Cancer Agents in …, 2017 - ingentaconnect.com
Herein, the development of ruthenium complexes as potential apoptosis inducers, as well as
their underlying mechanism has been reviewed. In recent years, various ruthenium …

Antitumor effectiveness and mechanism of action of Ru (II)/amino acid/diphosphine complexes in the peritoneal carcinomatosis progression

F Mello-Andrade, WL da Costa, WC Pires… - Tumor …, 2017 - journals.sagepub.com
Peritoneal carcinomatosis is considered as a potentially lethal clinical condition, and the
therapeutic options are limited. The antitumor effectiveness of the [Ru (l-Met)(bipy)(dppb)] …

Anticancer ruthenium complexes in drug discovery and medicinal chemistry

S Thota - Mini reviews in medicinal chemistry, 2016 - pubmed.ncbi.nlm.nih.gov
Editorial: Anticancer Ruthenium Complexes in Drug Discovery and Medicinal Chemistry
Editorial: Anticancer Ruthenium Complexes in Drug Discovery and Medicinal Chemistry Mini …

Ruthenium(II)/Benzonitrile Complex Induces Cytotoxic Effect in Sarcoma-180 Cells by Caspase-Mediated and Tp53/p21-Mediated Apoptosis, with Moderate Brine …

RS Faria, HD Silva, F Mello-Andrade, WC Pires… - … Trace Element Research, 2020 - Springer
Ruthenium (II)/benzonitrile complexes have demonstrated promising anticancer properties.
Considering that there are no specific therapies for treating sarcoma, we decided to evaluate …