Neuromodulation in epilepsy: state-of-the-art approved therapies

P Ryvlin, S Rheims, LJ Hirsch, A Sokolov… - The Lancet …, 2021 - thelancet.com
Three neuromodulation therapies have been appropriately tested and approved in refractory
focal epilepsies: vagus nerve stimulation (VNS), deep brain stimulation of the anterior …

Tissue damage thresholds during therapeutic electrical stimulation

SF Cogan, KA Ludwig, CG Welle… - Journal of neural …, 2016 - iopscience.iop.org
Objective. Recent initiatives in bioelectronic modulation of the nervous system by the NIH
(SPARC), DARPA (ElectRx, SUBNETS) and the GlaxoSmithKline Bioelectronic Medicines …

[HTML][HTML] Vagus nerve stimulation drives selective circuit modulation through cholinergic reinforcement

S Bowles, J Hickman, X Peng, WR Williamson… - Neuron, 2022 - cell.com
Vagus nerve stimulation (VNS) is a neuromodulation therapy for a broad and expanding set
of neurologic conditions. However, the mechanism through which VNS influences central …

Non-invasive access to the vagus nerve central projections via electrical stimulation of the external ear: fMRI evidence in humans

E Frangos, J Ellrich, BR Komisaruk - Brain stimulation, 2015 - Elsevier
Background Tract-tracing studies in cats and rats demonstrated that the auricular branch of
the vagus nerve (ABVN) projects to the nucleus tractus solitarii (NTS); it has remained …

Long-term treatment with responsive brain stimulation in adults with refractory partial seizures

GK Bergey, MJ Morrell, EM Mizrahi, A Goldman… - Neurology, 2015 - neurology.org
Objective: The long-term efficacy and safety of responsive direct neurostimulation was
assessed in adults with medically refractory partial onset seizures. Methods: All participants …

Practical considerations in epilepsy neurostimulation

HD Simpson, A Schulze‐Bonhage, GD Cascino… - …, 2022 - Wiley Online Library
Neuromodulation is a key therapeutic tool for clinicians managing patients with drug‐
resistant epilepsy. Multiple devices are available with long‐term follow‐up and real‐world …

A review of parameter settings for invasive and non-invasive vagus nerve stimulation (VNS) applied in neurological and psychiatric disorders

SL Thompson, GH O'Leary, CW Austelle… - Frontiers in …, 2021 - frontiersin.org
Vagus nerve stimulation (VNS) is an established form of neuromodulation with a long history
of promising applications. Earliest reports of VNS in the literature date to the late 1800's in …

Neurostimulation in people with drug‐resistant epilepsy: systematic review and meta‐analysis from the ILAE surgical therapies commission

L Touma, B Dansereau, AY Chan, N Jetté, CS Kwon… - …, 2022 - Wiley Online Library
Objective Summarize the current evidence on efficacy and tolerability of vagus nerve
stimulation (VNS), responsive neurostimulation (RNS), and deep brain stimulation (DBS) …

Lower urinary tract symptoms in depression: a review

DJ Anderson, A Aucoin, CR Toups… - Health psychology …, 2023 - pmc.ncbi.nlm.nih.gov
Lower Urinary Tract Symptoms (LUTS) are frequently present in the general population as
patients age with approximately a third of individuals experiencing LUTS during their …

Application of machine learning to epileptic seizure onset detection and treatment

AH Shoeb - 2009 - dspace.mit.edu
Epilepsy is a chronic disorder of the central nervous system that predisposes individuals to
experiencing recurrent seizures. It affects 3 million Americans and 50 million people world …