Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly
colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis …

Wnt signaling transduces evolutionarily conserved pathways which play important roles in
initiating and regulating a diverse range of cellular activities, including cell proliferation …

Aberrant activation of the Wnt pathway is implicated in driving the formation of various
human cancers, particularly those of the digestive tract. Inhibition of aberrant Wnt pathway …

In colorectal tumours, Wnt pathway genetics continues to be dominated by mutations in the
adenomatous polyposis coli (APC) gene. Germline mutations cause familial adenomatous …

It has been two decades since investigators discovered the link between the Drosophila
wingless (Wg) gene and the vertebrate oncogene int-1, thus establishing the family of …

Decades of cancer research have unraveled genetic, epigenetic and molecular pathways
leading to plausible therapeutic targets; many of which hold great promise in improving …

Aberrant activation of the WNT/ß-catenin signaling pathway is frequently involved in a broad
spectrum of human malignancies. Alternative to genetic deletions and point mutations …

Activation of the Wnt/β-catenin signaling pathway is a hallmark of a number of solid tumors.
We analyzed the regulation of the Wnt/β-catenin pathway in acute lymphoblastic leukemia …

It has been reported that the progression of osteosarcoma was closely associated with the
aberrant activation of canonical Wnt signaling. Wnt inhibitory factor-1 (WIF-1) is a secreted …

Abstract Background Aberrations in the Wnt pathway have been reported to be involved in
the metastasis of prostate cancer (PCa) to bone. We investigated the effect and underlying …