Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics
Antagonistic antibodies targeting the inhibitory immune-checkpoint receptor PD-1 or its
ligand PD-L1 are used to treat a wide range of cancer types and can substantially improve …
ligand PD-L1 are used to treat a wide range of cancer types and can substantially improve …
Regulation of PD-L1 expression in the tumor microenvironment
M Yi, M Niu, L Xu, S Luo, K Wu - Journal of hematology & oncology, 2021 - Springer
Abstract Programmed death-ligand 1 (PD-L1) on cancer cells engages with programmed
cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple …
cell death-1 (PD-1) on immune cells, contributing to cancer immune escape. For multiple …
Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1
(PD-1)/programmed cell death-ligand 1 (PD-L1) are two most representative immune …
(PD-1)/programmed cell death-ligand 1 (PD-L1) are two most representative immune …
Aspects of the tumor microenvironment involved in immune resistance and drug resistance
K Khalaf, D Hana, JTT Chou, C Singh… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …
The diverse function of PD-1/PD-L pathway beyond cancer
The recent success of PD-1 and PD-L1 blockade in cancer therapy illustrates the important
role of the PD-1/PD-L1 pathway in the regulation of antitumor immune responses. However …
role of the PD-1/PD-L1 pathway in the regulation of antitumor immune responses. However …
The role of cancer-derived microRNAs in cancer immune escape
M Yi, L Xu, Y Jiao, S Luo, A Li, K Wu - Journal of hematology & oncology, 2020 - Springer
During malignant transformation, accumulated somatic mutations endow cancer cells with
increased invasiveness and immunogenicity. Under selective pressure, these highly …
increased invasiveness and immunogenicity. Under selective pressure, these highly …
Exosome-derived microRNAs of human milk and their effects on infant health and development
BC Melnik, W Stremmel, R Weiskirchen, SM John… - Biomolecules, 2021 - mdpi.com
Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …
development. Milk provides a wide spectrum of mammary epithelial cell-derived …
Updated review of advances in microRNAs and complex diseases: experimental results, databases, webservers and data fusion
MicroRNAs (miRNAs) are gene regulators involved in the pathogenesis of complex
diseases such as cancers, and thus serve as potential diagnostic markers and therapeutic …
diseases such as cancers, and thus serve as potential diagnostic markers and therapeutic …
Current insight into the regulation of PD-L1 in cancer
Z Liu, X Yu, L Xu, Y Li, C Zeng - Experimental hematology & oncology, 2022 - Springer
The molecular mechanisms underlying cancer immune escape are a core topic in cancer
immunology research. Cancer cells can escape T cell-mediated cellular cytotoxicity by …
immunology research. Cancer cells can escape T cell-mediated cellular cytotoxicity by …
PD/1-PD-Ls checkpoint: insight on the potential role of NK cells
The identification of inhibitory NK cell receptors specific for HLA-I molecules (KIRs and
NKG2A) provided the molecular basis for clarifying the mechanism by which NK cells kill …
NKG2A) provided the molecular basis for clarifying the mechanism by which NK cells kill …