Advancing human gut microbiota research by considering gut transit time

N Procházková, G Falony, LO Dragsted, TR Licht… - Gut, 2023 - gut.bmj.com
Accumulating evidence indicates that gut transit time is a key factor in sha** the gut
microbiota composition and activity, which are linked to human health. Both population-wide …

The impact of disease comorbidities in Alzheimer's disease

JA Santiago, JA Potashkin - Frontiers in aging neuroscience, 2021 - frontiersin.org
A wide range of comorbid diseases is associated with Alzheimer's disease (AD), the most
common neurodegenerative disease worldwide. Evidence from clinical and molecular …

Helicobacter pylori‐derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3‐C3aR signalling

J **e, L Cools, G Van Imschoot… - Journal of …, 2023 - Wiley Online Library
The gut microbiota represents a diverse and dynamic population of microorganisms that can
influence the health of the host. Increasing evidence supports the role of the gut microbiota …

Differences in alpha diversity of gut microbiota in neurological diseases

Z Li, J Zhou, H Liang, L Ye, L Lan, F Lu… - Frontiers in …, 2022 - frontiersin.org
Background Neurological diseases are difficult to diagnose in time, and there is currently a
lack of effective predictive methods. Previous studies have indicated that a variety of …

Neurodegenerative and neurodevelopmental diseases and the gut-brain axis: The potential of therapeutic targeting of the microbiome

B Bicknell, A Liebert, T Borody, G Herkes… - International journal of …, 2023 - mdpi.com
The human gut microbiome contains the largest number of bacteria in the body and has the
potential to greatly influence metabolism, not only locally but also systemically. There is an …

The α-synuclein origin and connectome model (SOC Model) of Parkinson's disease: explaining motor asymmetry, non-motor phenotypes, and cognitive decline

P Borghammer - Journal of Parkinson's disease, 2021 - content.iospress.com
A new model of Parkinson's disease (PD) pathogenesis is proposed, the α-Synuclein Origin
site and Connectome (SOC) model, incorporating two aspects of α-synuclein pathobiology …

Neurodegenerative disorders and gut-brain interactions

A Singh, TM Dawson, S Kulkarni - The Journal of clinical …, 2021 - Am Soc Clin Investig
Neurodegenerative disorders (NDs) affect essential functions not only in the CNS, but also
cause persistent gut dysfunctions, suggesting that they have an impact on both CNS and gut …

Helicobacter pylori infection: Beyond gastric manifestations

MLC Santos, BB de Brito, FAF da Silva… - World journal of …, 2020 - pmc.ncbi.nlm.nih.gov
Helicobacter pylori (H. pylori) is a bacterium that infects more than a half of world's
population. Although it is mainly related to the development of gastroduodenal diseases …

Gram-negative bacteria and their lipopolysaccharides in Alzheimer's disease: pathologic roles and therapeutic implications

H Kim, S Kim, SJ Shin, YH Park, Y Nam, C Kim… - Translational …, 2021 - Springer
Alzheimer's disease (AD) is the most serious age-related neurodegenerative disease and
causes destructive and irreversible cognitive decline. Failures in the development of …

[HTML][HTML] Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations

S Nishijima, E Stankevic, O Aasmets, TSB Schmidt… - Cell, 2025 - cell.com
The microbiota in individual habitats differ in both relative composition and absolute
abundance. While sequencing approaches determine the relative abundances of taxa and …