Ca2+/calmodulin-dependent protein kinase II (CaMKII) and long-term potentiation (LTP)
were discovered within a decade of each other and have been inextricably intertwined ever …

Summary The Ca 2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) was touted as
a memory molecule, even before its involvement in long-term potentiation (LTP) was shown …

Learning and memory are thought to require hippocampal long-term potentiation (LTP), and
one of the few central dogmas of molecular neuroscience that has stood undisputed for …

The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …

While CaMKII has long been known to be essential for synaptic plasticity and learning,
recent work points to new dimensions of CaMKII function in the nervous system, revealing …

Long-term potentiation (LTP) of synaptic transmission is considered to be a cellular
counterpart of learning and memory. Activation of postsynaptic NMDA type glutamate …

Activity-dependent plasticity of synaptic structure and function plays an essential role in
neuronal development and in cognitive functions including learning and memory. The …

Ca2+-regulated gene transcription is essential to diverse physiological processes, including
the adaptive plasticity associated with learning. We found that basal synaptic input activates …

The Ca 2+/Calmodulin (CaM)-dependent protein kinase II (CaMKII) is activated by Ca
2+/CaM, but becomes partially autonomous (Ca 2+-independent) upon autophosphorylation …

In the nervous system, many intracellular responses to elevated calcium are mediated by
CaM kinases (CaMKs), a family of protein kinases whose activities are initially modulated by …