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Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation
Transcranial magnetic stimulation (TMS) is a non-invasive technique for focal brain
stimulation based on electromagnetic induction where a fluctuating magnetic field induces a …
stimulation based on electromagnetic induction where a fluctuating magnetic field induces a …
Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder
AJ Cutler, GW Mattingly, V Maletic - Translational Psychiatry, 2023 - nature.com
The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …
Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments
The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …
related disorders remain unclear, but studies in depressed patients and rodent models are …
Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions
Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …
ketamine as a rapid-acting antidepressant and the development and refinement of tools …
The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology
Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …
the most well-documented neural abnormalities in major depressive disorder (MDD) …
Consensus recommendations for the clinical application of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression
Objective: To provide expert recommendations for the safe and effective application of
repetitive transcranial magnetic stimulation (rTMS) in the treatment of major depressive …
repetitive transcranial magnetic stimulation (rTMS) in the treatment of major depressive …
Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders
Cognitive dysfunctions, including impaired attention, learning, memory, planning and
problem solving, occur in depressive episodes, often persist during remission, predict …
problem solving, occur in depressive episodes, often persist during remission, predict …
Glutamate and GABA homeostasis and neurometabolism in major depressive disorder
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …
Modulators of GABAA receptor-mediated inhibition in the treatment of neuropsychiatric disorders: past, present, and future
SM Thompson - Neuropsychopharmacology, 2024 - nature.com
The predominant inhibitory neurotransmitter in the brain, γ-aminobutyric acid (GABA), acts at
ionotropic GABAA receptors to counterbalance excitation and regulate neuronal firing …
ionotropic GABAA receptors to counterbalance excitation and regulate neuronal firing …
Somatostatin-positive gamma-aminobutyric acid interneuron deficits in depression: cortical microcircuit and therapeutic perspectives
The functional integration of external and internal signals forms the basis of information
processing and is essential for higher cognitive functions. This occurs in finely tuned cortical …
processing and is essential for higher cognitive functions. This occurs in finely tuned cortical …