Assessing the mechanisms of brain plasticity by transcranial magnetic stimulation

A Jannati, LM Oberman, A Rotenberg… - …, 2023 - nature.com
Transcranial magnetic stimulation (TMS) is a non-invasive technique for focal brain
stimulation based on electromagnetic induction where a fluctuating magnetic field induces a …

Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder

AJ Cutler, GW Mattingly, V Maletic - Translational Psychiatry, 2023 - nature.com
The pathophysiology of major depressive disorder (MDD) is thought to result from impaired
connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key …

Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions

BD Hare, RS Duman - Molecular psychiatry, 2020 - nature.com
Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …

The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology

EL Belleau, MT Treadway, DA Pizzagalli - Biological psychiatry, 2019 - Elsevier
Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

Consensus recommendations for the clinical application of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression

SM McClintock, IM Reti, LL Carpenter… - The Journal of clinical …, 2017 - psychiatrist.com
Objective: To provide expert recommendations for the safe and effective application of
repetitive transcranial magnetic stimulation (rTMS) in the treatment of major depressive …

Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders

T Prévot, E Sibille - Molecular psychiatry, 2021 - nature.com
Cognitive dysfunctions, including impaired attention, learning, memory, planning and
problem solving, occur in depressive episodes, often persist during remission, predict …

Glutamate and GABA homeostasis and neurometabolism in major depressive disorder

A Sarawagi, ND Soni, AB Patel - Frontiers in psychiatry, 2021 - frontiersin.org
Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …

Modulators of GABAA receptor-mediated inhibition in the treatment of neuropsychiatric disorders: past, present, and future

SM Thompson - Neuropsychopharmacology, 2024 - nature.com
The predominant inhibitory neurotransmitter in the brain, γ-aminobutyric acid (GABA), acts at
ionotropic GABAA receptors to counterbalance excitation and regulate neuronal firing …

Somatostatin-positive gamma-aminobutyric acid interneuron deficits in depression: cortical microcircuit and therapeutic perspectives

C Fee, M Banasr, E Sibille - Biological psychiatry, 2017 - Elsevier
The functional integration of external and internal signals forms the basis of information
processing and is essential for higher cognitive functions. This occurs in finely tuned cortical …