The dependence of viral RNA replication on co-opted host factors
PD Nagy, J Pogany - Nature Reviews Microbiology, 2012 - nature.com
Abstract Positive-sense RNA ((+) RNA) viruses such as hepatitis C virus exploit host cells by
subverting host proteins, remodelling subcellular membranes, co-opting and modulating …
subverting host proteins, remodelling subcellular membranes, co-opting and modulating …
The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2
A handful of singular structures and laws can be observed in nature. They are not always
evident but, once discovered, it seems obvious how to take advantage of them. In chemistry …
evident but, once discovered, it seems obvious how to take advantage of them. In chemistry …
Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis
The pathogenesis of SARS-CoV-2 remains to be completely understood, and detailed SARS-
CoV-2 cellular cytopathic effects requires definition. We performed a comparative …
CoV-2 cellular cytopathic effects requires definition. We performed a comparative …
[HTML][HTML] Cholesterol manipulation by West Nile virus perturbs the cellular immune response
Complex membrane structures induced by West Nile virus (WNV), an enveloped RNA virus,
are required for efficient viral replication. How these membranes are induced and how they …
are required for efficient viral replication. How these membranes are induced and how they …
Inhibition of Cytosolic Phospholipase A2α Impairs an Early Step of Coronavirus Replication in Cell Culture
Coronavirus replication is associated with intracellular membrane rearrangements in
infected cells, resulting in the formation of double-membrane vesicles (DMVs) and other …
infected cells, resulting in the formation of double-membrane vesicles (DMVs) and other …
Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy
JP Pezacki, JA Blake, DC Danielson… - Nature chemical …, 2011 - nature.com
Cellular biomolecules contain unique molecular vibrations that can be visualized by
coherent anti-Stokes Raman scattering (CARS) microscopy without the need for labels. Here …
coherent anti-Stokes Raman scattering (CARS) microscopy without the need for labels. Here …
A randomized clinical trial of lipid metabolism modulation with fenofibrate for acute coronavirus disease 2019
JA Chirinos, P Lopez-Jaramillo… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cytotoxicity may involve
inhibition of peroxisome proliferator-activated receptor alpha. Fenofibrate activates …
inhibition of peroxisome proliferator-activated receptor alpha. Fenofibrate activates …
Multiple roles of 25‐hydroxycholesterol in lipid metabolism, antivirus process, inflammatory response, and cell survival
Q Cao, Z Liu, Y ** cell homeostasis, being the
precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind …
precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind …
Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication
J Borawski, P Troke, X Puyang, V Gibaja… - Journal of …, 2009 - Am Soc Microbiol
Host factor pathways are known to be essential for hepatitis C virus (HCV) infection and
replication in human liver cells. To search for novel host factor proteins required for HCV …
replication in human liver cells. To search for novel host factor proteins required for HCV …
Modulation of Lipid Droplet Metabolism—A Potential Target for Therapeutic Intervention in Flaviviridae Infections
Lipid droplets (LDs) are endoplasmic reticulum (ER)-related dynamic organelles that store
and regulate fatty acids and neutral lipids. They play a central role in cellular energy storage …
and regulate fatty acids and neutral lipids. They play a central role in cellular energy storage …