Robust radiotherapy planning

J Unkelbach, M Alber, M Bangert… - Physics in Medicine …, 2018 - iopscience.iop.org
Motion and uncertainty in radiotherapy is traditionally handled via margins. The clinical
target volume (CTV) is expanded to a larger planning target volume (PTV), which is …

Automation in intensity modulated radiotherapy treatment planning—a review of recent innovations

M Hussein, BJM Heijmen, D Verellen… - The British journal of …, 2018 - academic.oup.com
Radiotherapy treatment planning of complex radiotherapy techniques, such as intensity
modulated radiotherapy and volumetric modulated arc therapy, is a resource-intensive …

Minmax robustness for multi-objective optimization problems

M Ehrgott, J Ide, A Schöbel - European Journal of Operational Research, 2014 - Elsevier
In real-world applications of optimization, optimal solutions are often of limited value,
because disturbances of or changes to input data may diminish the quality of an optimal …

[HTML][HTML] Practical robustness evaluation in radiotherapy–A photon and proton-proof alternative to PTV-based plan evaluation

EW Korevaar, SJM Habraken, D Scandurra… - Radiotherapy and …, 2019 - Elsevier
Background and purpose A planning target volume (PTV) in photon treatments aims to
ensure that the clinical target volume (CTV) receives adequate dose despite treatment …

Robustness for uncertain multi-objective optimization: a survey and analysis of different concepts

J Ide, A Schöbel - OR spectrum, 2016 - Springer
In this paper, we discuss various concepts of robustness for uncertain multi-objective
optimization problems. We extend the concepts of flimsily, highly, and lightly robust …

Integrated scheduling of energy supply and demand in microgrids under uncertainty: A robust multi-objective optimization approach

L Wang, Q Li, R Ding, M Sun, G Wang - Energy, 2017 - Elsevier
Abstract As a Demand Response (DR) based working mode, the integrated scheduling of
energy supply and demand provides an effective approach to improve economic and …

Robust proton treatment planning: physical and biological optimization

J Unkelbach, H Paganetti - Seminars in radiation oncology, 2018 - Elsevier
Accurate prediction of tumor control and toxicities in radiation therapy faces many
uncertainties. Besides interpatient variability in the response to radiation, there are also …

Effectiveness of robust optimization in intensity‐modulated proton therapy planning for head and neck cancers

W Liu, SJ Frank, X Li, Y Li, PC Park, L Dong… - Medical …, 2013 - Wiley Online Library
Purpose: Intensity‐modulated proton therapy (IMPT) is highly sensitive to uncertainties in
beam range and patient setup. Conventionally, these uncertainties are dealt using …

Multi-criteria optimization and decision-making in radiotherapy

S Breedveld, D Craft, R Van Haveren… - European Journal of …, 2019 - Elsevier
Radiotherapy (radiation therapy) is one of the main treatments for cancer. The aim is to
deliver a prescribed radiation dose to the tumor, while kee** the unavoidable dose to the …

Physics controversies in proton therapy

M Engelsman, M Schwarz, L Dong - Seminars in radiation oncology, 2013 - Elsevier
The physical characteristics of proton beams are appealing for cancer therapy. The rapid
increase in operational and planned proton therapy facilities may suggest that this …