Although a wealth of data have elucidated the structure and physiology of neuronal circuits,
we still only have a very limited understanding of how behavioral learning is implemented at …

Learning and memory are associated with the formation and modification of neuronal
assemblies: populations of neurons that encode what has been learned and mediate …

Neurons in sensory cortex integrate multiple influences to parse objects and support
perception. Across multiple cortical areas, integration is characterized by two neuronal …

Correlated variability in cortical activity is ubiquitously quenched following stimulus onset, in
a stimulus-dependent manner. These modulations have been attributed to circuit dynamics …

Many studies have shown that the excitation and inhibition received by cortical neurons
remain roughly balanced across many conditions. A key question for understanding the …

We tested the sensory impact of repeated synchronization of fast-spiking interneurons (FS),
an activity pattern thought to underlie neocortical gamma oscillations. We optogenetically …

The idea that there is a fundamental cortical circuit that performs canonical computations
remains compelling though far from proven. Here we review evidence for two canonical …

We compare the circuit and cellular mechanisms for homeostatic plasticity that have been
discovered in rodent somatosensory (S1) and visual (V1) cortex. Both areas use similar …

Neurons maintain their average firing rate and other properties within narrow bounds
despite changing conditions. This homeostatic regulation is achieved using negative …

Parvalbumin (PV)-positive interneurons modulate cortical activity through highly specialized
connectivity patterns onto excitatory pyramidal neurons (PNs) and other inhibitory cells. PV …