Neuroimmunology of traumatic brain injury: time for a paradigm shift

YN Jassam, S Izzy, M Whalen, DB McGavern… - Neuron, 2017 - cell.com
Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …

Sex differences in traumatic brain injury: what we know and what we should know

RP Gupte, WM Brooks, RR Vukas, JD Pierce… - Journal of …, 2019 - liebertpub.com
There is growing recognition of the problem of male bias in neuroscience research,
including in the field of traumatic brain injury (TBI) where fewer women than men are …

Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury

H Wu, J Zheng, S Xu, Y Fang, Y Wu, J Zeng… - Journal of …, 2021 - Springer
Background Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …

Uncovering sex differences of rodent microglia

J Han, Y Fan, K Zhou, K Blomgren… - Journal of …, 2021 - Springer
There are inherent structural and functional differences in the central nervous systems
(CNS) of females and males. It has been gradually established that these sex-specific …

Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males

H Abou-El-Hassan, RM Rezende, S Izzy… - Nature …, 2023 - nature.com
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. The innate and
adaptive immune responses play an important role in the pathogenesis of TBI. Gamma-delta …

The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

WT O'Brien, L Pham, GF Symons, M Monif… - Journal of …, 2020 - Springer
There is a great clinical need to identify the underlying mechanisms, as well as related
biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a …

The role of selected pro-inflammatory cytokines in pathogenesis of ischemic stroke

H Pawluk, A Woźniak, G Grześk… - … interventions in aging, 2020 - Taylor & Francis
Stroke is currently one of the most common causes of death and disability in the world, and
its pathophysiology is a complex process, involving the oxidative stress and inflammatory …

[HTML][HTML] Blood-based biomarkers of inflammation in mild traumatic brain injury: A systematic review

K Visser, M Koggel, J Blaauw, HJ van der Horn… - Neuroscience & …, 2022 - Elsevier
Abstract VISSER, K., M. Koggel, J. Blaauw, HJvd Horn, B. Jacobs, and Jvd Naalt. Blood
based biomarkers of inflammation in mild traumatic brain injury: A systematic review …

Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation

MF Lanfranco, J Sepulveda, G Kopetsky, GW Rebeck - Glia, 2021 - Wiley Online Library
Neuroinflammation is a common feature in neurodegenerative diseases, modulated by the
Alzheimer's disease risk factor, apolipoprotein E (APOE). In the brain, apoE protein is …

Current understanding of neuroinflammation after traumatic brain injury and cell-based therapeutic opportunities

Y **ong, A Mahmood, M Chopp - Chinese Journal of Traumatology, 2018 - mednexus.org
Traumatic brain injury (TBI) remains a major cause of death and disability worldwide.
Increasing evidence indicates that TBI is an important risk factor for neurodegenerative …