The development of effective treatments for cancers requires investigations for a more
detailed and comprehensive understanding of the basic cellular mechanisms involved in …

Epithelial ovarian cancer (EOC) is a leading cause of cancer-related death in women. Late-
stage diagnosis with significant tumor burden, accompanied by recurrence and …

Growth factors in tumor environments are regulators of cell survival and metastasis. Here,
we reveal the dichotomy between TGF-β superfamily growth factors BMP and TGF-β/activin …

CDK8 is a transcription-regulating kinase that controls TGF-β/BMP-responsive SMAD
transcriptional activation and turnover through YAP1 recruitment. However, how the …

Intergenic transcription in normal and cancerous tissues is pervasive but incompletely
understood. To investigate this, we constructed an atlas of over 180,000 consensus RNA …

Metastatic growth of ovarian cancer cells into the peritoneal cavity requires adaptation to
various cellular stress factors to facilitate cell survival and growth. Here, we demonstrate the …

The presence of an immature tumor vascular network contributes to cancer dissemination
and the development of resistance to therapies. Strategies to normalize the tumor …

Apoptosis, or programmed cell death, maintains tissue homeostasis by eliminating damaged
or unnecessary cells. However, cells can evade this process, contributing to conditions such …

Background Angiogenesis has become an attractive target for cancer therapy. However,
despite the initial success of anti-VEGF (Vascular endothelial growth factor) therapies, the …

Background: Gliomablastoma multiforme (GBM) is the most fatal form of all brain cancers in
human with no successful treatment available. Programmed death-ligand 1 (PD-L1) is a …