Mitogen‐activated protein kinases (MAPKs; ERK1/2, p38, JNK, and ERK5) have evolved to
transduce environmental and developmental signals (growth factors, stress) into adaptive …

Large macromolecular assemblies, so-called molecular machines, are critical to ensuring
proper cellular function. Understanding how proper function is achieved at the atomic level …

NMR titration experiments are a rich source of structural, mechanistic, thermodynamic and
kinetic information on biomolecular interactions, which can be extracted through the …

Dengue virus is an important human pathogen threating people, especially in tropical and
sub-tropical regions. The viral genome has one open reading frame and encodes one …

In the last years, a growing interest has been gathering around the ability of Molecular
Dynamics (MD) to provide insight into the paths of long-range structural communication in …

In its unliganded form, the retinoic acid receptor (RAR) in heterodimer with the retinoid X
receptor (RXR) exerts a strong repressive activity facilitated by the recruitment of …

In-cell nuclear magnetic resonance (NMR) is a method to provide the structural information
of a target at an atomic level under physiological conditions and a full view of the …

Nuclear magnetic resonance (NMR) spectroscopy is a pivotal method for structure-based
and fragment-based lead discovery because it is one of the most robust techniques to …

Methyl groups are powerful probes for the analysis of structure, dynamics and function of
supramolecular assemblies, using both solution-and solid-state NMR. Widespread …

Ras genes potently drive human cancers, with mutated proto-oncogene GTPase KRAS4B (K-
Ras4B) being the most abundant isoform. Targeted inhibition of oncogenic gene products is …