Antifibrotic effects of sodium-glucose cotransporter-2 inhibitors: A comprehensive review

N Shakour, S Karami, M Iranshahi, AE Butler… - Diabetes & Metabolic …, 2024 - Elsevier
Background and aims Scar tissue accumulation in organs is the underlying cause of many
fibrotic diseases. Due to the extensive array of organs affected, the long-term nature of …

Cardiovascular risk in the peritoneal dialysis patient

RT Krediet, O Balafa - Nature Reviews Nephrology, 2010 - nature.com
Cardiovascular death is the most frequent cause of death in patients on peritoneal dialysis.
Risk factors for cardiovascular death in these patients include those that affect the general …

Risk of stroke in long-term dialysis patients compared with the general population

HH Wang, SY Hung, JM Sung, KY Hung… - American Journal of …, 2014 - Elsevier
Background Patients undergoing maintenance dialysis are at increased risk of stroke. Study
Design We performed a nationwide retrospective cohort study to determine the risks for …

Empagliflozin, a sodium glucose cotransporter-2 inhibitor, ameliorates peritoneal fibrosis via suppressing TGF-β/Smad signaling

Y Shentu, Y Li, S **e, H Jiang, S Sun, R Lin… - International …, 2021 - Elsevier
Abstract Sodium glucose cotransporter-2 (SGLT-2) inhibitor has been reported to exert a
glucose-lowering effect in the peritoneum exposed to peritoneal dialysis solution. However …

[HTML][HTML] Peritoneal expression of SGLT-2, GLUT1, and GLUT3 in peritoneal dialysis patients

S Schricker, T Oberacker, P Fritz, M Ketteler… - Kidney and Blood …, 2022 - karger.com
Introduction: In peritoneal dialysis (PD) patients, the peritoneal membrane is affected by
glucose-based solutions used as peritoneal dialysate fluids. This exposure leads to changes …

The association of peritoneal dialysis and hemodialysis on mitral and aortic valve calcification associated mortality: a meta-analysis

KJ Chiu, SC Chen, WY Su, YY Chang, KC Chang… - Scientific reports, 2024 - nature.com
Cardiac valve calcification (CVC), characterized by the accumulation of calcium in the heart
valves, is highly prevalent among patients undergoing dialysis. This meta-analysis aimed to …

Triglyceride glucose-body mass index and cardiovascular mortality in patients undergoing peritoneal dialysis: a retrospective cohort study

C Zhan, Y Peng, H Ye, X Diao, C Yi, Q Guo… - Lipids in Health and …, 2023 - Springer
Background Recent studies have shown that triglyceride glucose-body mass index (TyG-
BMI) is associated with the risk of ischemic stroke and coronary artery disease. However …

Astragaloside IV ameliorates peritoneal fibrosis by promoting PGC‐1α to reduce apoptosis in vitro and in vivo

M **e, B **a, L **ao, D Yang, Z Li… - Journal of Cellular …, 2023 - Wiley Online Library
Prolonged exposure of the peritoneum to high glucose dialysate leads to the development of
peritoneal fibrosis (PF), and apoptosis of peritoneal mesothelial cells (PMCs) is a major …

Associations between different insulin resistance indices and the risk of all-cause mortality in peritoneal dialysis patients

G Zhao, S Shang, N Tian, X Zhan, F Peng… - Lipids in Health and …, 2024 - Springer
Background Insulin resistance (IR) is prevalent in individuals undergoing peritoneal dialysis
(PD) and is related to increased susceptibility to coronary artery disease and initial …

Meal time shift disturbs circadian rhythmicity along with metabolic and behavioral alterations in mice

JA Yoon, DH Han, JY Noh, MH Kim, GH Son, K Kim… - 2012 - journals.plos.org
In modern society, growing numbers of people are engaged in various forms of shift works or
trans-meridian travels. Such circadian misalignment is known to disturb endogenous diurnal …