Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Supersulphides are inorganic and organic sulphides with sulphur catenation with diverse
physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA …

In eukaryotic cells, oxidative protein folding occurs in the lumen of the endoplasmic
reticulum (ER), catalyzed by ER sulfhydryl oxidase 1 (Ero1) and protein disulfide isomerase …

The current coronavirus pandemic is exerting a tremendously detrimental impact on global
health. The Spike proteins of coronaviruses, responsible for cell receptor binding and viral …

Living organisms use selenium mainly in the form of selenocysteine in the active site of
oxidoreductases. Here, selenium's unique chemistry is believed to modulate the reaction …

Mass spectrometry-based chemoproteomics has emerged as an enabling technology for
functional biology and drug discovery. To address limitations of established …

Map** the ligandability or potential druggability of all proteins in the human proteome is a
central goal of mass spectrometry-based covalent chemoproteomics. Achieving this …

The entry of SARS-CoV-2 into host cells involves the interaction between the viral spike
protein and the human angiotensin-converting enzyme 2 (ACE2) receptor. Given that the …

Inflammasome activation is one of the first steps in initiating innate immune responses. In
this work, we studied the activation of inflammasomes in the airways of critically ill COVID-19 …