It is now possible to estimate an individual's brain age via brain scans and machine-learning
models. This validated technique has opened up new avenues for addressing clinical …

Evidence suggests that psychopathology is associated with an advanced brain ageing
process, typically mapped using machine learning models that predict an individual's age …

Importance To make progress toward precision psychiatry, it is crucial to move beyond case-
control studies and instead capture individual variations and interpret them in the context of …

Background A growing body of studies revealed that enteric dysbacteriosis could result in
depression via the “gut–microbiota–brain axis”(GMBA). Whether probiotics, prebiotics, and …

Decreased cerebral blood flow (CBF) may be an important mechanism associated with
depression. In this study we aimed to determine if the association of CBF and depression is …

Understanding how traumatic stress affects typical brain development during adolescence is
critical to elucidate underlying mechanisms related to both maladaptive functioning and …

The geroscience hypothesis asserts that physiological aging is caused by a small number of
biological pathways. Despite the explosion of geroscience research over the past couple of …

Neuroimaging studies consistently show advanced brain age in schizophrenia, suggesting
that brain structure is often 'older'than expected at a given chronological age. Whether …

Background Cardiometabolic multimorbidity (CMM) and depression are often co-occurring
in older adults and associated with neurodegenerative outcomes. The present study aimed …

The term “accelerated aging” reflects the higher rates of agingrelated clinical, biological, and
functional decline observed in patients with many chronic conditions, including …