Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …

FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …

The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor
growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated …

Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …

In the mammalian intestine, crypts of Leiberkühn house intestinal epithelial stem/progenitor
cells at their base. The mammalian intestine also harbors a diverse array of microbial …

MicroRNAs (miRNAs) are crucial post-transcriptional regulators of haematopoietic cell fate
decisions. They act by negatively regulating the expression of key immune development …