Chemotherapy has historically been the mainstay of cancer treatment, but our
understanding of what drives a successful therapeutic response remains limited. The …

Pancreatic ductal adenocarcinoma (PDAC) has one of the worst prognoses among all
malignancies. PI3K/AKT/mTOR signaling pathway, a main downstream effector of KRAS is …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and deadliest
cancer worldwide with an overall survival rate, all stages combined, of still< 10% at 5 years …

Pancreatic cancer (PC) remains a leading cause of mortality worldwide due to the absence
of early detection methods and the low success rates of traditional therapeutic strategies …

Pancreatic cancer is fast becoming a global menace and it is projected to be the second
leading cause of cancer-related death by 2030. Pancreatic adenocarcinomas, which …

Ultrasound is widely used in the diagnosis and therapy of cancer. Tumors can be treated by
thermal or mechanical tissue ablation. Furthermore, tumors can be manipulated by …

The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) poses a
major obstacle to traditional and immunomodulatory cancer therapies and is closely …

Hyaluronan (HA) has complex biological roles that have catalyzed clinical interest in several
fields of medicine. In this narrative review, we provide an overview of HA aggregation, also …

Nucleosomes play a crucial role in regulating gene expression through their composition
and post-translational modifications. When cells die, intracellular endonucleases are …

Pancreatic cancer presents formidable challenges due to rapid progression and resistance
to conventional treatments. Oncolytic viruses (OVs) selectively infect cancer cells and cause …