Combining existing drug therapy is essential in develo** new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

Simple Summary This review explores the challenges of drug resistance in cancer treatment
and discusses innovative strategies to overcome them. Researchers aim to understand how …

Nuclear factor erythroid 2-related factor 2 (NRF2) hyperactivation has been established as
an oncogenic driver in a variety of human cancers, including non-small cell lung cancer …

Female breast cancer is the most deadly cancer in women worldwide. The triple-negative
breast cancer subtype therapies, due to the lack of specific drug targets, are still based on …

Endometrial cancer (EC) is the 6th most common cancer in women around the world. Alone
in the United States (US), 66,200 new cases and 13,030 deaths are expected to occur in …

Camptothecin (CPT), an alkaloid isolated from the Camptotheca tree, has demonstrated
significant anticancer properties in a range of malignancies. However, its therapeutic …

Highlights•In silico prediction of drug combination has become indispensable due to the
expensive cost of experiments.•Deep learning architectures used for drug combination …

This review explores the concept of synergy in pharmacology, emphasizing its importance in
optimizing treatment outcomes through the combination of drugs with different mechanisms …

Combinational therapies with synergistic effects provide a powerful treatment strategy for
tackling complex diseases, particularly malignancies. Discovering these synergistic …

Introduction Chinese medicine, rooted in a rich history dating back thousands of years, offers
a holistic approach to healthcare that has endured the test of time. This comprehensive …