RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?

F Fabbiano, J Corsi, E Gurrieri… - Journal of …, 2020 - Wiley Online Library
Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …

An emphasis on the interaction of signaling pathways highlights the role of miRNAs in the etiology and treatment resistance of gastric cancer

D Fathi, MS Elballal, AE Elesawy, AI Abulsoud… - Life Sciences, 2023 - Elsevier
Gastric cancer (GC) is 4th in incidence and mortality rates globally. Several genetic and
epigenetic factors, including microRNAs (miRNAs), affect its initiation and progression …

A review of the biological role of miRNAs in prostate cancer suppression and progression

AS Doghish, A Ismail, HA El-Mahdy, MA Elkady… - International journal of …, 2022 - Elsevier
Prostate cancer (PC) is the third-leading cause of cancer-related deaths worldwide.
Although the current treatment strategies are progressing rapidly, PC is still representing a …

High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer

A Datta, H Kim, L McGee, AE Johnson, S Talwar… - Scientific reports, 2018 - nature.com
Targeting exosome biogenesis and release may have potential clinical implications for
cancer therapy. Herein, we have optimized a quantitative high throughput screen (qHTS) …

Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate …

A Datta, H Kim, M Lal, L McGee, A Johnson… - Cancer letters, 2017 - Elsevier
Emerging evidence links exosomes to cancer progression by the trafficking of oncogenic
factors and neoplastic reprogramming of stem cells. This necessitates identification and …

Exosomes: diagnostic biomarkers and therapeutic delivery vehicles for cancer

L Jiang, Y Gu, Y Du, J Liu - Molecular pharmaceutics, 2019 - ACS Publications
Exosomes are described as nanoscale extracellular vesicles (EVs) secreted by multiple cell
types and extensively distributed in various biological fluids. They contain multifarious …

Androgen receptor variant-driven prostate cancer: clinical implications and therapeutic targeting

ES Antonarakis, AJ Armstrong, SM Dehm… - Prostate cancer and …, 2016 - nature.com
While there are myriad mechanisms of primary and acquired resistance to conventional and
next-generation hormonal therapies in prostate cancer, the potential role of androgen …

Clinical relevance of androgen receptor alterations in prostate cancer

E Jernberg, A Bergh, P Wikström - Endocrine connections, 2017 - ec.bioscientifica.com
Prostate cancer (PC) remains a leading cause of cancer-related deaths among men
worldwide, despite continuously improved treatment strategies. Patients with metastatic …

Role of noncoding RNA in drug resistance of prostate cancer

L Ding, R Wang, D Shen, S Cheng, H Wang, Z Lu… - Cell death & …, 2021 - nature.com
Prostate cancer is one of the most prevalent forms of cancer around the world. Androgen-
deprivation treatment and chemotherapy are the curative approaches used to suppress …

The HNRNPF/H RNA binding proteins and disease

T Brownmiller, NJ Caplen - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
The members of the HNRNPF/H family of heterogeneous nuclear RNA proteins—HNRNPF,
HNRNPH1, HNRNPH2, HNRNPH3, and GRSF1, are critical regulators of RNA maturation …