Non-alcoholic fatty liver disease (NAFLD), or hepatic steatosis, has become one of the most
common pathologies among liver-related disorders. The rapid accumulation of fat in this …

We investigated the role of TONSL, a mediator of homologous recombination repair (HRR),
in stalled replication fork double-strand breaks (DSBs) in cancer. Publicly available clinical …

Primary aldosteronism (PA), characterized by autonomous aldosterone overproduction, is a
major cause of secondary hypertension with significant cardiovascular complications …

Cancer-induced skeletal muscle defects differ in severity between individuals with the same
cancer type. Cancer subtype-specific genomic aberrations are suggested to mediate these …

Introduction Breast cancer is among the most prevalent malignant tumors globally, with
carboplatin serving as a standard treatment option. However, resistance often compromises …

Breast cancer is one of the most common malignant tumors in women worldwide. Similarly,
Canine mammary tumors (CMTs) are mostly diagnosed as spontaneous diseases in female …

Somatic mutations contribute to cancer development by altering the activity of enhancers. In
the study, a total of 135 mutation-driven enhancers, which displayed significant chromatin …

Purpose The tonsoku-like DNA repair protein (TONSL) encoded by the TONSL gene,
located on chromosome 8q24. 3, is crucial for repairing DNA double-strand breaks through …

Teleost fish show an enormous diversity of sex determination systems, varying from
environmental sex determination to full sex chromosomes. Traditionally sex chromosomes …

Background Deep learning architectures have advanced genotype‒phenotype map**s
with precision but often obscure the roles of specific genes and their interactions. Our …