Hepatocellular carcinoma (HCC) is a lethal human malignancy with a very low overall and
long-term survival rate. Poor prognostic outcomes are predominantly associated with HCC …

Liquid biopsy technologies have the potential to transform cancer patient management as it
offers non-invasive diagnosis and real-time monitoring of disease progression and treatment …

Chronic hepatitis C virus (cHCV) is a leading cause for liver cirrhosis (LC) and
hepatocellular carcinoma (HCC) globally. So far, there is no optimal non-invasive biomarker …

Radioresistance conferred by cancer stem cells (CSCs) is the principal cause of the failure
of cancer radiotherapy. Eradication of CSCs is a prime therapeutic target and a requirement …

MiR-22 is mostly considered as a hepatic tumor-suppressor microRNA based on in vitro
analyses. Yet, whether miR-22 exerts a tumor-suppressive function in the liver has not been …

Simple Summary The high heterogeneity of hepatocellular carcinoma (HCC), and the lack of
druggable mutations, hamper the identification of unequivocal molecular classifiers and limit …

Cancer stem cells (CSCs) play significant roles in tumor initiation. MicroRNA-135a (miR-
135a) induced the formation of a CD133+ subpopulation from a human papillomavirus …

Pancreatic ductal adenocarcinoma is the third leading cause of cancer-related death. Its
dismal prognosis is closely related to late diagnosis, which results from both non-specific …

The present thesis derives from 3-year phD project focused on biomarker discovery for
Pancreatic Ductal Adenocarcinoma diagnosis and prognosis. Pancreatic ductal …

Objective Hepatocellular carcinoma (HCC) has a high morbidity and mortality around the
world, yet the effective therapeutic option for HCC is still limited. NPAC, also known as …