[HTML][HTML] Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases

U Sengupta, R Kayed - Progress in neurobiology, 2022 - Elsevier
Aggregation of specific proteins are histopathological hallmarks of several
neurodegenerative diseases, such as, Amyloid β (Aβ) plaques and tau neurofibrillary …

Chemical design of activatable photoacoustic probes for precise biomedical applications

Y Liu, L Teng, B Yin, H Meng, X Yin, S Huan… - Chemical …, 2022 - ACS Publications
Photoacoustic (PA) imaging technology, a three-dimensional hybrid imaging modality that
integrates the advantage of optical and acoustic imaging, has great application prospects in …

PEP-FOLD4: A pH-dependent force field for peptide structure prediction in aqueous solution

J Rey, S Murail, S de Vries, P Derreumaux… - Nucleic acids …, 2023 - academic.oup.com
Accurate and fast structure prediction of peptides of less 40 amino acids in aqueous solution
has many biological applications, but their conformations are pH-and salt concentration …

Bioinspired flexible hydrogelation with programmable properties for tactile sensing

Y Wang, Q Geng, H Lyu, W Sun, X Fan, K Ma… - Advanced …, 2024 - Wiley Online Library
Tactile sensing requires integrated detection platforms with distributed and highly sensitive
haptic sensing capabilities along with biocompatibility, aiming to replicate the physiological …

In-cell structural biology by NMR: the benefits of the atomic scale

FX Theillet - Chemical reviews, 2022 - ACS Publications
In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

High-frequency terahertz waves disrupt Alzheimer's β-amyloid fibril formation

W Peng, Z Zhu, J Lou, K Chen, Y Wu, C Chang - eLight, 2023 - Springer
The accumulation and deposition of amyloid can cause a variety of neurodegenerative
diseases, including Alzheimer's and Parkinson's disease. The degradation or clearance of …

Ins and outs of AlphaFold2 transmembrane protein structure predictions

T Hegedűs, M Geisler, GL Lukács, B Farkas - Cellular and Molecular Life …, 2022 - Springer
Transmembrane (TM) proteins are major drug targets, but their structure determination, a
prerequisite for rational drug design, remains challenging. Recently, the DeepMind's …

Imaging amyloid‐β membrane interactions: ion‐channel pores and lipid‐bilayer permeability in Alzheimer's disease

JH Viles - Angewandte Chemie International Edition, 2023 - Wiley Online Library
The accumulation of the amyloid‐β peptides (Aβ) is central to the development of
Alzheimer's disease. The mechanism by which Aβ triggers a cascade of events that leads to …

A hairpin motif in the amyloid-β peptide is important for formation of disease-related oligomers

M Khaled, I Rönnbäck, LL Ilag… - Journal of the …, 2023 - ACS Publications
The amyloid-β (Aβ) peptide is associated with the development of Alzheimer's disease and
is known to form highly neurotoxic prefibrillar oligomeric aggregates, which are difficult to …

C3N nanodots inhibits Aβ peptides aggregation pathogenic path in Alzheimer's disease

X Yin, H Zhou, M Zhang, J Su, X Wang, S Li… - Nature …, 2023 - nature.com
Despite the accumulating evidence linking the development of Alzheimer's disease (AD) to
the aggregation of Aβ peptides and the emergence of Aβ oligomers, the FDA has approved …