Accelerated reaction kinetics in microdroplets: Overview and recent developments

Z Wei, Y Li, RG Cooks, X Yan - Annual Review of Physical …, 2020 - annualreviews.org
Various organic reactions, including important synthetic reactions involving C–C, C–N, and
C–O bond formation as well as reactions of biomolecules, are accelerated when the …

Molecular reactions at aqueous interfaces

MF Ruiz-Lopez, JS Francisco… - Nature Reviews …, 2020 - nature.com
This Review aims to critically analyse the emerging field of chemical reactivity at aqueous
interfaces. The subject has evolved rapidly since the discovery of the so-called 'on-water …

Can electric fields drive chemistry for an aqueous microdroplet?

H Hao, I Leven, T Head-Gordon - Nature communications, 2022 - nature.com
Reaction rates of common organic reactions have been reported to increase by one to six
orders of magnitude in aqueous microdroplets compared to bulk solution, but the reasons for …

Optimizing chemical reactions with deep reinforcement learning

Z Zhou, X Li, RN Zare - ACS central science, 2017 - ACS Publications
Deep reinforcement learning was employed to optimize chemical reactions. Our model
iteratively records the results of a chemical reaction and chooses new experimental …

High electric field on water microdroplets catalyzes spontaneous and ultrafast oxidative C–H/N–H cross-coupling

D Zhang, X Yuan, C Gong, X Zhang - Journal of the American …, 2022 - ACS Publications
Oxidative C–H/N–H cross-coupling has emerged as an atom-economical method for the
construction of C–N bonds. Conventional oxidative C–H/N–H coupling requires at least one …

Spontaneous reduction-induced degradation of viologen compounds in water microdroplets and its inhibition by host–guest complexation

C Gong, D Li, X Li, D Zhang, D **ng… - Journal of the …, 2022 - ACS Publications
Water serves as an inert environment for the dispersion and application of many kinds of
herbicides. Viologen compounds, a type of widely used but highly toxic herbicide, are stable …

Multiphase chemistry under nanoconfinement: An electrochemical perspective

SM Lu, KJ Vannoy, JE Dick… - Journal of the American …, 2023 - ACS Publications
Most relevant systems of interest to modern chemists rarely consist of a single phase. Real-
world problems that require a rigorous understanding of chemical reactivity in multiple …

Capture of hydroxyl radicals by hydronium cations in water microdroplets

D **ng, Y Meng, X Yuan, S **, X Song… - Angewandte …, 2022 - Wiley Online Library
Despite the high stability of bulk water, water microdroplets possess strikingly different
properties, such as the presence of hydroxyl radicals (OH⋅) at the air–water interface …

Mass spectrometry using electrospray ionization

GRD Prabhu, ER Williams, M Wilm… - Nature Reviews Methods …, 2023 - nature.com
Applying a high voltage to a liquid passing through a capillary disintegrates the liquid
meniscus to generate a fine spray of charged droplets. As the droplets evaporate, polar …

Direct C(sp3)–N Bond Formation between Toluene and Amine in Water Microdroplets

Y Meng, E Gnanamani, RN Zare - Journal of the American …, 2022 - ACS Publications
Unlike the inertness of bulk water, water microdroplets exhibit some remarkable reactivities.
We report that water microdroplets can directly produce stable C7H7+ cations (a …